International Journal of Health Sciences and Research Vol.11; Issue: 3; March 2021 Website: www.ijhsr.org Review Article ISSN: 2249-9571 International Journal of Health Sciences and Research (www.ijhsr.org) 128 Vol.11; Issue: 3; March 2021 Ectopic Pregnancy: A Review of Clinical Presentation and Management in Niger Delta University Teaching Hospital, Bayelsa State Nigeria Eugene M. Ikeanyi 1 , Howells E. Ikobho 2 1,2 Department of Obstetrics and Gynecology, Niger Delta University Teaching Hospital Okolobiri, Bayelsa State, Nigeria Corresponding Author: Eugene M. Ikeanyi ABSTRACT Background: Ectopic pregnancy poses a major health and reproductive challenge to childbearing women. It is a significant hemorrhagic disorder that continues to contribute substantially to maternal morbidity and mortality. This is an error of zygote implantation outside the endometrial cavity with consequent rupture and or death of the fetus because of the failure of implantation site to sustain further fetal growth and development. Unless timely interventions, the consequences of ruptured ectopic pregnancy can be life-threatening. Objectives: To measure the incidence of ectopic pregnancy in the Niger Delta University Teaching Hospital, determine its contribution to early pregnancy loss, case-fatality rate and investigate the possible associated risk factors and other relevant correlates. Methods: Data on each ectopic pregnancy that presented from 2015 to 2020 were collected and analyzed. Results: Ectopic pregnancy constituted 6.3% and 23.9% of gynaecological admissions and surgeries respectively and an incidence of 2.8% of live births and 2.3% of all pregnancies managed. Median age of patients was 29 (interquartile 25-34) years, the leading identifiable risk factors were previous induced abortion (72.7%), intra-abdominal surgery (23.6%) and multiple sex partners (21.5%). The commonest clinical presentation was abdominal pain (96.4%), dizziness/fainting spell (58.2%) and vaginal bleeding (41.8%). Mean estimated blood loss was 1593.6±702.8mls, 85.5% of the patients were anemic at presentation and 89.1% received blood transfusion. Tubal pregnancy was 94.5%, left tube 51.9%, ampullary 69.2% and isthmic 17.3%. All the patients had laparotomy, 92.7 % salpingectomy (49.1% left and 43.6% right). There was one death; a case fatality of 1.56%. Conclusion: Ectopic pregnancy still remains a major cause of maternal morbidity and mortality. Prior tubal damage, mostly from pelvic infection is the risk factor. Quality contraception, blood banking services and legalization of abortion will mitigate the impact of ectopic pregnancy Keywords: ectopic, pregnancy, incidence, salpingectomy, case-fatality, risk factor INTRODUCTION Ectopic pregnancy (EP) is an extrauterine pregnancy and can result in massive hemorrhage, infertility or mortality. It occurs when the product of conception implants in any other site other than uterine endometrial cavity. [1] Overall, it complicates about 1.1- 2% of all pregnancies. [2-3] In Nigeria, reported incidence is 1.5%-3.3% [4-6] and 1.6%- 2.2% of live births in developed societies. [7] For the women who survive EP, there is increased risk of the compromise of their future fertility. Without timely diagnosis and treatment, EP can be life threatening from massive hemorrhage. It is the leading cause of maternal death in the first trimester of pregnancy. [2] On diagnosis it can be amenable to expectant, medical or surgical