_____________________________________________________________________________________________________ *Corresponding author: Email: chukwuma.okeafor@uniport.edu.ng; Int. J. Trop. Dis. Health, vol. 44, no. 7, pp. 39-47, 2023 International Journal of TROPICAL DISEASE & Health Volume 44, Issue 7, Page 39-47, 2023; Article no.IJTDH.99092 ISSN: 2278–1005, NLM ID: 101632866 Socio-demographic and HIV-Related Factors Associated with Depression among Retroviral Positive Adolescents in Port Harcourt Chukwuma U. Okeafor a* and Onyeunoegbunem Godstime b a Department of Mental Health/Neuropsychiatry, University of Port Harcourt Teaching Hospital, Rivers, Nigeria. b Department of Paediatrics, University of Port Harcourt Teaching Hospital, Rivers, Nigeria. Authors’ contributions This work was carried out in collaboration between both authors. Both authors read and approved the final manuscript. Article Information DOI: 10.9734/IJTDH/2023/v44i71423 Open Peer Review History: This journal follows the Advanced Open Peer Review policy. Identity of the Reviewers, Editor(s) and additional Reviewers, peer review comments, different versions of the manuscript, comments of the editors, etc are available here: https://www.sdiarticle5.com/review-history/99092 Received: 21/02/2023 Accepted: 26/04/2023 Published: 27/04/2023 ABSTRACT Introduction: Depression with HIV constitute a co-morbid condition associated with severe sequalae, which include deliberate self-harm and suicide, even among adolescents. Identifying demographic and HIV-related determinants of depression among adolescents living with HIV is vital for instituting relevant evidence-based interventions for curbing this problem. Thus this aimed to determine the relationship between these factors (socio-demographic and HIV-related factors) and depression among adolescents living with HIV. Methods: A cross-sectional hospital-based study was employed. It involved 140 HIV-infected adolescents, who were selected from the HIV Paediatric clinic of the University of Port Harcourt Teaching Hospital (UPTH) via systematic sampling method. Depression was determined based on the depression component of the depression anxiety stress scale (DASS-21), while social support Original Research Article