(multivariate and univariate), used in 51% of the studies. The Morisky scale (36%) was the most widely adopted measurement tool and cardiovascular disease/hypertension was the most investigated condition (38%). No studies using advanced data mining techniques to study adherence in chronic conditions were found. Bibliometric analysis of the medication adherence literature showed an average of 6.7 citations per article. The most prolific countries were the USA with 225 citations and China with 40 citations. Analysis of key-words article titles and abstracts showed patients’ beliefs and preferences as a key theme and a worthwhile area of investigation. Conclusions: The use of big data techniques to understand medication adherence is still under-researched. A new framework for classifying methods, measurement tools and key variables in medication adherence research is proposed, along with rec- ommendations for new studies to better understand adherence patterns in big data and how to translate these into actionable interventions. PMU139 VALIDITY OF THE SLOVENIAN VERSION OF THE CARERQOL-7D QUESTIONNAIRE AMONG INFORMAL CAREGIVERS IN THE SLOVENIAN GENERAL POPULATION Prevolnik Rupel V, 1 Zrubka Z, 2 Ogorevc M, 3 Gulácsi L, 2 Baji P, 4 Golicki D, 5 Brouwer W, 6 van Exel NJA, 7 Péntek M 8 1 Institute for Economic Research, Ljubljana, Slovenia, 2 Corvinus University of Budapest, Budapest, Hungary, 3 Institute for Economic Research, Ljubljana, Ljubljana, Slovenia, 4 Department of Health Economics, Corvinus University of Budapest, Budapest, PE, Hungary, 5 Medical University of Warsaw, Department of Experimental and Clinical Pharmacology, Warsaw, Poland, 6 Erasmus School of Health Policy and Management, Rotterdam, Netherlands, 7 Erasmus University Rotterdam, Rotterdam, Hungary, 8 Corvinus University of Budapest, Budapest, PE, Hungary Objectives: The CarerQol-7D instrument was developed to measure care-related quality of life of informal caregivers. This study aimed to assess the validity of the Slovenian version of the CarerQol-7D. Methods: The Slovenian language version of the CarerQol-7D was developed. A cross-sectional online survey was performed among a representative sample of the general Slovenian population (N=1,000). The psychometric characteristics of the CarerQol-7D were evaluated in relation to EQ-5D- 5L health status and the caregiving situation. Subgroup comparisons were carried out with Kruskal-Wallis rank sum test. Spearman’s rank correlation coefficients were calculated between continuous variables. A 5% significance level was applied. Results: 138 informal caregivers were identified (male 50%, mean age 46.9), among them 96 were currently providing and 42 had provided informal care in the past year. Except for care duration, no statistically significant differences were found between present and former informal care providers. Considering only the current caregivers, CarerQol index score correlated significantly with CarerQol VAS, EQ-5D- 5L and EQ VAS; and differed significantly by the overall care experience (rather negative: 59.4, neither negative nor positive: 73.8, rather positive: 80.9) and ac- cording to whether the caregiver and care recipient were living in the same household (yes: 67.1, no: 73.4). Discriminative validity was supported by significant differences in overall CarerQol scores for the different levels of the seven dimensions of the instrument. Analyses of the total sample confirmed these findings and addi- tional factors turned into significant: his/her health problems were permanent (Yes: 73.5, No: 64.6, Do not know: 71.1), the duration of informal care (in months #1: 61.3; 2-6: 68.3; 7-12: 63.9; .12: 74.0). Conclusions: Slovenian language version of the CarerQol-7D yielded valid and reliable data among informal caregivers in Slovenia. Further confirmatory studies involving larger samples are suggested, focusing also on reliability and responsiveness of the instrument. PMU140 A COMPREHENSIVE CATALOGUE OF EQ-5D SCORES IN CHRONIC DISEASE: RESULTS OF A SYSTEMATIC REVIEW Van Wilder L, 1 Rammant E, 2 Clays E, 2 Devleesschauwer B, 3 Pauwels N, 2 De Smedt D 2 1 Ghent University, Ghent, VOV, Belgium, 2 Ghent University, Ghent, Belgium, 3 Sciensano, Brussels, Belgium Objectives: Chronic diseases are associated with impaired health-related quality of life (HRQoL) outcomes. Comparison of HRQoL outcomes between different diseases and with the general population is of major importance to health economists, epi- demiologists, clinicians, and policy makers. The aim of this systematic literature review was to develop a catalogue with EQ-5D scores in chronic non-communicable diseases, and to compare these scores with reference values from the general pop- ulation. Methods: MEDLINE, Embase, and Web of Science were systematically searched independently by two reviewers. Studies were included if they reported mean EQ-5D index values for the adult population and if these scores were compared with the general population. The QualSyst tool for quantitative research was used for quality appraisal. Results: Hundred and eighty-one articles met the inclusion criteria. An extensive catalogue summarizes the EQ-5D scores in a wide variety of chronic diseases. Mean EQ-5D index values ranged between -0.20 and 1. Lower EQ-5D scores are reported in chronic diseases compared to the general pop- ulation, specifically in neurological disorders. Most of the diseases demonstrate a substantial disutility, although a minority of diseases have equal or even higher index scores than the general population. Conclusions: A comprehensive, international catalogue has been developed to provide EQ-5D index scores for diverse chronic diseases compared with reference values based on the available literature. These scores can be used for health economic evaluations and for policy objectives. Future studies should focus on unexamined diseases and specific patient groups to expand the evidence base on HRQoL in chronic diseases. PMU141 DEVELOPMENT OF EQ-5D-5L BOLT-ONS FOR COGNITION AND VISION Sampson C, 1 Addo R, 2 Haywood P, 2 Herdman M, 3 Janssen B, 4 Mulhern B, 2 Page K, 2 Reardon O, 2 Rodes Sanchez M, 3 Schneider J, 5 Shah K, 1 Thetford C 6 1 The Office of Health Economics, London, LON, UK, 2 Univeristy of Technology Sydney, Sydney, Australia, 3 The Office of Health Economics, London, UK, 4 The EuroQol Group, Rotterdam, Netherlands, 5 University of Nottingham, Nottingham, UK, 6 University of Central Lancashire, Preston, UK Objectives: Evidence suggests that, in specific circumstances, the EQ-5D is insensi- tive to changes or differences in health status. One possible solution is to add ‘bolt- on’ dimensions to the core EQ-5D dimensions, to provide additional information about the impact of certain conditions or symptoms on health. In this study, we developed EQ-5D-5L bolt-ons for cognition (5L-Cog) and vision (5L-Vis). Methods: The development process involved three stages. First, systematic literature reviews were conducted for outcome measures used in cognitive impairment and visual impairment. Items were extracted from existing measures and mapped to a set of dimensions. Common terminology was also recorded. Second, we conducted focus groups in the UK with people who have experience of either impairment. Partici- pants were encouraged to describe the impact of their own experience of cognitive impairment or visual impairment, with reference to dimensions and terminologies identified in the literature reviews. The findings were used to develop candidate 5L- Cog and 5L-Vis descriptors. Third, we conducted interviews in the UK and Australia with people who have experience of either impairment. Interviewees were asked to complete the EQ-5D-5L with candidate 5L-Cog or 5L-Vis descriptors, followed by cognitive debriefing. Results: Candidate descriptors related to dimensions such as memory (for 5L-Cog), visual acuity (for 5L-Vis), mood (for both), and social func- tioning (for both). Various terminologies were identified in the review, with ‘prob- lems’, ‘limitations’, ‘difficulties’, and ‘feelings’ being used in both contexts. Focus group participants expressed preferences for different terms and identified prob- lematic words. Conclusions: Qualitative research methods can be used to develop bolt-on descriptors for the EQ-5D that are meaningful to people with lived experi- ence. However, it is challenging to identify a suitable range of participants where people with relevant lived experience constitute a heterogeneous population. In a subsequent phase of the study, 5L-Cog and 5L-Vis descriptors will be tested quan- titatively. PMU142 ASSESSING THE HUMAN AND ECONOMIC BURDEN OF SHORT STATURE: A SYSTEMATIC LITERATURE REVIEW Lundkvist J, 1 Shohet S, 2 Cookson C, 3 Law L, 4 Ribeiro-Oliveira A 5 1 Ipsen Pharma, Uppsala, Sweden, 2 Ipsen Pharmaceuticals, Slough, UK, 3 Oxford PharmaGenesis, Oxford, UK, 4 Oxford PharmaGenesis, CAMBRIDGE, UK, 5 Ipsen, Cambridge, MA, USA Objectives: We sought to better understand the human and economic burden of short stature (SS) using a systematic literature review. Methods: Studies of the hu- man and economic burden of SS in adults and children, due to any cause, were searched using Embase, MEDLINE and Cochrane databases in December 2018, capturing publications from 2008 onwards. Case series and populations with adult- onset growth hormone deficiency (GHD) were excluded. Results: Of 1239 publica- tions identified, 26 studies (17 in children, 9 in adults) met inclusion criteria, with sample sizes of the SS populations ranging from 15 to 285. Thirteen studies were in mixed populations, four in GHD only, four in chronic kidney disease (CKD), and one each in Turner syndrome, Prader-Willi syndrome, skeletal dysplasia, congenital ad- renal hyperplasia, and childhood-onset multiple pituitary hormone deficiency. No economic studies were identified. Twelve studies compared quality of life (QoL) in children with SS and those with normal height; 10 found that QoL was significantly poorer in children with SS and two (both in CKD populations) found no association. Of five studies that investigated height as a predictor of QoL among children with SS, all found greater height was associated with better QoL. One study highlighted negative social experiences in children with SS. Two studies evaluated cognitive function, finding cognitive scores were significantly poorer in children with SS than in those with normal height. In adults, six studies demonstrated impaired QoL with SS versus normal height, while two found no association and one reported mixed results. Conclusions: The literature suggests that compared with those with normal height, children and adults with SS of any cause experience poorer QoL and in children it may negatively impact social and cognitive functioning. Further research could extend our understanding of the human and economic burden in this field. VALUE IN HEALTH - NOVEMBER 2019 S733