Researchrticle The Importance of Correlation between Aldosterone and Parathyroid Hormone in Patients with Primary Hyperparathyroidism Branka Milicic Stanic , 1,2 Branislava Ilincic, 2,3 Radmila Zeravica, 2,3 Dragana Milicic Ivanovski, 4 Velibor Cabarkapa, 2,3 and Romana Mijovic 2,3 1 DepartmentofMedicine,GeorgetownUniversityMedicalCenter,4000ReservoirRoad,NW,Washington,DC20057,US 2 UniversityofNoviSad,FacultyofMedicine,HajdukVeljkova3,NoviSad21000,Serbia 3 CenterforLaboratoryMedicine,ClinicalCenterofVojvodina,HajdukVeljkova1–9,NoviSad21000,Serbia 4 CenterforPathophysiologyofBreathingandRespiratorySleepDisorders,TeInstituteforPulmonaryDiseasesofVojvodina, PutdrGoldmana4,SrKamenica21204,Serbia Correspondence should be addressed to Branka Milicic Stanic; bs1132@georgetown.edu Received 17 June 2022; Accepted 21 October 2022; Published 7 November 2022 Academic Editor: Giorgio Borretta Copyright © 2022 Branka Milicic Stanic et al. Tis is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. In primary hyperparathyroidism, an increased risk of developing the cardiovascular disease may exist due to increased activity of the renin•angiotensin•aldosterone system. Te aim of this study was to evaluate the relationship between parathyroid hormone and aldosterone in patients with primary hyperparathyroidism. Te study included 48 patients with primary hyperparathyroidism and 30 healthy subjects who matched age and gender to the study group. Tis study was conducted at the Center for Laboratory medicine, Clinical center of Vojvodina, Novi Sad, Serbia. In addition to clinical data and laboratory determination of the concentration of total and ionized calcium, phosphorus, measurements of parathyroid hormone, vitamin D, direct renin, and aldosterone were performed by the method of chemiluminescent technology. Compared to the controls, the study group had statistically signifcantly higher values of aldosterone (p � 0.028), total calcium (p � 0.01), ionized calcium (p � 0.003) and parathyroid hormone (P ≤ 0.001) Serum aldosterone and parathyroid hormone levels were correlated positively in patients with primary hyperparathyroidism (r � 0.509, p < 0.05). A statistically signifcant positive correlation between renin and parathyroid hormone (r � 0.688, p < 0.05) and renin and calcium (r � 0.673, p < 0.05) was determined in hyperparathyroid patients. In multivariate regression analysis, the strongest predictive variable of aldosterone secretion was parathyroid hormone (p � 0.011). An independent relationship between parathyroid hormone and aldosterone in patients with primary hyperparathyroidism and the correlation between renin and parathyroid hormone as well as with calcium indicate not only the direct but also the indirect associations between parathyroid hormone and aldosterone in primary hyperparathyroidism. Tese fndings may represent another possible model of renin•angiotensin•aldosterone•induced organ damage. 1. Introduction Parathyroid glands synthesize the parathyroid hormone (PTH) which is the primary regulator of calcium homeo• stasis. After the structure and function of the PTH hormone was clarifed, it became clear that PTH also manifests other efects in addition to the action on the bones and kidney, such as the efect on the cardiovascular system 1, 2]. PTH is a peptide hormone secreted by the chief cells of the parathyroid glands 3]. Te major physiological regu• lator of PTH secretion is the concentration of serum ionized calcium (Ca 2+ ) 4]. Ca 2+ is a ligand for the calcium•sensitive receptor (CaSR), presented on the surface of the parathyroid glands, C•cells of the thyroid gland, and also in the kidneys and the brain. Decreased concentration of calcium (Ca 2+ ) in the blood will be registered by CaSR receptors and trigger Hindawi International Journal of Endocrinology Volume 2022, Article ID 3804899, 8 pages https://doi.org/10.1155/2022/3804899