International Journal of Sciences: Basic and Applied Research (IJSBAR) ISSN 2307-4531 (Print & Online) http://gssrr.org/index.php?journal=JournalOfBasicAndApplied --------------------------------------------------------------------------------------------------------------------------- 68 The Relationship of Inflammatory Regulation and Pain Intensity in SIRS Patients Dwi Pantja Wibowo a* , Suryani As’ad b , Fransiscus Suhadi c , I Wayan Suranadi d , Ilhamjaya Patellongi e , Irawan Yusuf f , Mohammad Ramli Ahmad g , Syafrie Kamsul Arif h , Andi Husni Tanra i a,c Anesthesiology and Intensive Care Department, Bintaro Premier Hospital, Banten, Indonesia b Clinical Nutrition Department, Hasanuddin University, Makassar, Indonesia d Anesthesiology and Intensive Care Department, Udayana University, Denpasar, Indonesia e, f Physiology Department, Hasanuddin University, Makassar, Indonesia g,h,i Anesthesiology and Intensive Care Management Department, Hasanuddin University, Makassar, Indonesia a Email: dwipantja@yahoo.com Abstract Aims of this study were to investigate the changes in inflammatory regulation as shown by proinflammatory cytokines (IL-6) and anti-inflammatory cytokines (IL-10) from patients with systemic inflammatory responses syndrome (SIRS) that affect pain intensity changes with the marked increase of critical-care pain observation tools (CPOT) and decreased of the pain pressure threshold (PPT). A cross-sectional analysis to compare the values of IL-6, IL-10, PPT, and CPOT of SIRS patients and patients without SIRS. Of the 46 patients who were the subjects of the study, there were 21 SIRS patients and 25 patients non-SIRS. Patients with SIRS had higher CPOT values than patients without SIRS; CPOT values (3.3 vs. 1.2), significant with p = 0.001 (p < 0.05). The PPT scores of patients with SIRS were lower than those without SIRS (4.24 vs. 7.37), significant with p = 0.001 (p < 0.05). We conclude that in SIRS patients there is an increase in both proinflammatory (IL-6) and anti- inflammatory (IL-10) cytokines, but none of those cytokines had a relationship with pain intensity. Keyword: SIRS; CPOT; IL-6; IL-10. ----------------------------------------------------------------------- * Corresponding author. brought to you by CORE View metadata, citation and similar papers at core.ac.uk provided by GSSRR.ORG: International Journals: Publishing Research Papers in all Fields