Akshata V. Raut, Int. J. of Pharm. Sci., 2024, Vol 2, Issue 1, 328-341 | Review *Corresponding Author: Akshata V. Raut Address: Late Bhagirathi Yashwantrao Pathrikar College of Pharmacy. Email     : akshataraut1072@gmail.com Relevant conflicts of interest/financial disclosures: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES 328 | Page Microsponge technology has been developed for topical drug products in order to promote controlled release of the drug's active ingredient into the skin, thereby reducing systemic exposure and minimizing local cutaneous reactions to active drugs. Microsponge is made up of macroporous beads that are normally 10-25 micron in diameter and loaded with an active agent. When applied to the skin, the microsponge releases its active ingredients on a timer as well as in response to other signals. Microsponge drug delivery technology holds great promise for achieving the goal of controlled and site-specific drug delivery, and thus has sparked the curiosity of many investigators. This article provides a comprehensive overview of the Microsponges delivery system, including principles and preparation methods. Particle size and distribution, surface morphology, porosity, and density are all covered using appropriate approaches for characterization of microsponges. These microsponges are used in sunscreens, creams, ointments, as well as over-the-counter skin care preparations for topical application. Microsponge drug delivery can provide greater efficacy for topically active agents while also improving safety, product stability, and aesthetic properties in an efficient and novel way. They are mostly used topically, but have recently been used for oral administration. INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES [ISSN: 0975-4725; CODEN(USA):IJPS00]] Journal Homepage: https://www.ijpsjournal.com Review Article Microsponges: The Drug Delivery System Akshata V. Raut* , Nakul Kathar , Ganjanan Sanap Late Bhagirathi Yashwantrao Pathrikar College of Pharmacy ARTICLE INFO ABSTRACT Received: 30 Dec 2023 Accepted: 03 Jan 2024 Published: 17 Jan 2024 Keywords: Microsponge, controlled release, Topical drug delivery, solvent diffusion method, Quasi emulsion. DOI: 10.5281/zenodo.10523750 INTRODUCTION A microsponge the delivery system consists of unusual, highly cross-linked, porous, polymeric microspheres that can entrap a broader spectrum of activities and then release them at a controlled rate. This system is useful for improving the performance of relevant applicable drugs. It is a novel method for the controlled release of relevant agents that consists of micro porosity beads, typically 10 to 25 microns in diameter and filled with active agent. Because of the high degree of crosslinking, the particles are insoluble, inert, and strong enough to withstand the high shear commonly used in the manufacture of creams, gels, lotions, and powder.(1) Microsponges are small spheres capable of absorbing skin secretions and thus reducing skin oiliness and shine. Spherical particles made out of clusters of even