Antioxidants 2022, 11, 913. https://doi.org/10.3390/antiox11050913 www.mdpi.com/journal/antioxidants Review The Prospects of Swietenia macrophylla King in Skin Care Camille Keisha Mahendra 1 , Khang Wen Goh 2 , Long Chiau Ming 3, *, Gokhan Zengin 4 , Liang Ee Low 5,6 , Hooi-Leng Ser 7,8 and Bey Hing Goh 1,9,10, * 1 Biofunctional Molecule Exploratory Research Group, School of Pharmacy, Monash University Malaysia, Bandar Sunway 47500, Malaysia; camille.mahendra@monash.edu 2 Faculty of Data Science and Information Technology, INTI International University, Nilai 71800, Malaysia; khangwen.goh@newinti.edu.my 3 PAP Rashidah Sa’adatul Bolkiah Institute of Health Sciences, Universiti Brunei Darussalam, Gadong BE1410, Brunei 4 Biochemistry and Physiology Research Laboratory, Department of Biology, Science Faculty, Selcuk University, Konya 42130, Turkey; gokhanzengin@selcuk.edu.tr 5 Chemical Engineering Discipline, School of Engineering, Monash University Malaysia, Bandar Sunway 47500, Malaysia; low.liangee@monash.edu 6 Advanced Engineering Platform, Monash University Malaysia, Bandar Sunway 47500, Malaysia 7 Department of Biological Sciences, School of Medical and Life Sciences, Sunway University, Bandar Sunway 47500, Malaysia; hooilengs@sunway.edu.my 8 Novel Bacteria and Drug Discovery Research Group, Microbiome and Bioresource Research Strength Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Bandar Sunway 47500, Malaysia 9 College of Pharmaceutical Sciences, Zhejiang University, 866 Yuhangtang Road, Hangzhou 310058, China 10 Health and Well-Being Cluster, Global Asia in the 21st Century (GA21) Platform, Monash University Malaysia, Bandar Sunway 47500, Malaysia * Correspondence: longchiauming@gmail.com (L.C.M.); goh.bey.hing@monash.edu (B.H.G.) Abstract: The importance of cosmetics in our lives is immeasurable. Covering items from daily per- sonal hygienic products to skincare, it has become essential to consumers that the items that they use are safe and effective. Since natural products are from natural sources, and therefore considered “natural” and “green” in the public’s eyes, the rise in demand for such products is not surprising. Even so, factoring in the need to remain on trend and innovative, cosmetic companies are on a con- stant search for new ingredients and inventive new formulations. Based on numerous literature, the seed of Swietenia macrophylla has been shown to possess several potential “cosmetic-worthy” bi- oproperties, such as skin whitening, photoprotective, antioxidant, antimicrobial, etc. These proper- ties are vital in the cosmetic business, as they ultimately contribute to the “ageless” beauty that many consumers yearn for. Therefore, with further refinement and research, these active phyto- compounds may be a great contribution to the cosmetic field in the near future. Keywords: cosmeceutical; photoaging; anti-pigmentation; Swietenia macrophylla; natural product; skin whitening; skin repair and regeneration; wound healing; acne vulgaris; anti-microbial 1. Introduction Cosmetics, since time immemorable, have always been a large part of our lives. With global sales revenue projected to achieve $429.8 billion by 2022, the cosmetic industry is a lucrative, fast-paced, and innovative business that constantly seeks to fulfill consumer’s expectations and preferences [1,2]. Although many do not know it, the umbrella of cos- metics actually covers a large range of products categorized as personal hygiene, makeup, fragrances, skincare, and hair care [3]. Nevertheless, in the last few decades, the trend for “natural”, “green”, “sustainable”, and “safe” cosmetics is on the rise. With rising aware- ness and concerns regarding the ingredients within a product, there is an inclination for cosmetics that are developed from a natural source. This forces the cosmetic industry to Citation: Mahendra, C.K.; Goh, K.W.; Ming, L.C.; Zengin, G.; Low, L.E.; Ser, H.-L.; Goh, B.H. The Prospects of Swietenia macrophylla King in Skin Care. Antioxidants 2022, 11, 913. https://doi.org/10.3390/ antiox11050913 Academic Editors: Irene Dini and Sonia Laneri Received: 9 April 2022 Accepted: 3 May 2022 Published: 6 May 2022 Publisher’s Note: MDPI stays neu- tral with regard to jurisdictional claims in published maps and institu- tional affiliations. Copyright: © 2022 by the authors. Li- censee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and con- ditions of the Creative Commons At- tribution (CC BY) license (https://cre- ativecommons.org/licenses/by/4.0/).