Available online at www.scholarsresearchlibrary.com Scholars Research Library Der Pharmacia Lettre, 2011, 3(1): 38-44 (http://scholarsresearchlibrary.com/archive.html) ISSN 0975-5071 USA CODEN: DPLEB4 38 Scholar Research Library Fabrication and Evaluation of Gliquidone Azadirachta indica Fruit Mucilage and Poly Vinyl Pyrrolidone Sustained Release Matrix Tablets Hindustan Abdul Ahad 1 , Sreenivasulu R 1 , Kishore Kumar Reddy B 1 , Ramesh Gupta P 1 , Krishna Mahesh CH 1 , Ravi Kumar K 2 , Vijay Kumar MSS 3 1 College of pharmacy, Sri Krishnadevaraya University, Anantapur, Andhra Pradesh, INDIA 2 NIPER, Hyderabad, Andhra Pradesh, INDIA 3 MNR College of Pharmacy, Hyderabad, Andhra Pradesh, INDIA ______________________________________________________________________________ ABSTRACT The purpose of the present investigation was to design matrix type oral tablets of Gliquidone with Azadirachta indica fruit mucilage and Poly Vinyl Pyrrolidone. The polymers were studied for its functionality as a matrix forming property to sustain the Gliquidone release from formulated matrix tablets. Physicochemical properties of dried powdered mucilage of Azadirachta indica fruit mucilage and Poly Vinyl Pyrrolidone blend were studied. Various formulations of Gliquidone Azadirachta indica fruit mucilage and Poly Vinyl Pyrrolidone were prepared. The designed tablets were found to have better pharmacopoeial parameters with low standard deviation values. The swelling behavior and release rate characteristics were studied. The in-vitro dissolution study proved that the dried Azadirachta indica fruit mucilage and Poly Vinyl Pyrrolidone combination can be used as a matrix forming polymers for making sustained release matrix tablets. Key words: Gliquidone, Azadirachta indica, Poly Vinyl Pyrrolidone, matrix tablets, sustained release. ______________________________________________________________________________ INTRODUCTION The mucilage of Azadirachta indica fruits clinically and experimentally proved anti-diabetic activity [1] and release retardant property in the present investigation. Gliquidone is an oral hypoglycemic agent, which is a commonly prescribed drug for the treatment of patients with type II diabetes mellitus. It belongs to sulfonyl ureas drug class. Gliquidone is a weak acid with PKa of 5.3. Gliquidone is practically insoluble in water and acidic environment but highly permeable (class 2) according to the Biopharmaceutical classification System (BCS) [2]. The oral absorption is uniform, rapid and complete with nearly 100% bioavailability. The usual dose of Gliquidone is up to 180 mg daily [3]. The pharmacokinetics and dosage schedule supports