1 Novel anti-infective implant substrates: Controlled release of antibiofilm compounds from mesoporous silica-containing macroporous titanium Annabel Braem a,§,* , Kaat De Cremer b,c,§ , Nicolas Delattin b , Katrijn De Brucker b , Bram Neirinck a , Katleen Vandamme d , Johan A. Martens e , Jan Michiels b , Jef Vleugels a , Bruno P.A. Cammue b,c,* and Karin Thevissen b a Department of Materials Engineering (MTM), KU Leuven, Kasteelpark Arenberg 44 Box 2450, 3001 Leuven, Belgium. E-mail: Annabel.Braem@mtm.kuleuven.be, Bram.Neirinck@mtm.kuleuven.be, Jozef.Vleugels@mtm.kuleuven.be b Centre of Microbial and Plant Genetics (CMPG), KU Leuven, Kasteelpark Arenberg 20 Box 2460, 3001 Leuven, Belgium. E-mail: Kaat.Decremer@biw.kuleuven.be, Nicolas.Delattin@biw.kuleuven.be, Katrijn.Debrucker@biw.kuleuven.be, Jan.Michiels@biw.kuleuven.be, Bruno.Cammue@biw.kuleuven.be, Karin.Thevissen@biw.kuleuven.be c Department of Plant Systems Biology, VIB, Technologiepark 927, 9052 Ghent, Belgium. d BIOMAT Research Cluster, Department of Oral Health Sciences and Prosthetic Dentistry, KU Leuven and University Hospitals Leuven, Kapucijnenvoer 7 Box 7001, 3000 Leuven, Belgium. E-mail: Katleen.Vandamme@med.kuleuven.be e Centre of Surface Chemistry and Catalysis (COK), KU Leuven, Kasteelpark Arenberg 23 Box 2461, 3001 Leuven, Belgium. E-mail: Johan.Martens@biw.kuleuven.be § These authors contributed equally. * Corresponding authors: Dr. Annabel Braem, Department of Materials Engineering (MTM), KU Leuven, Kasteelpark Arenberg 44 box 2450, 3001 Leuven, Belgium. Phone: +3216321534. Fax: +3216321990. E-mail: Annabel.Braem@mtm.kuleuven.be; Prof. Bruno Cammue, Centre of Microbial and Plant Genetics (CMPG), KU Leuven, Kasteelpark Arenberg 20 box 2460, 3001 Leuven, Belgium. Phone: +3216329682. Fax: +3216321966. E- mail: Bruno.Cammue@biw.kuleuven.be. Statistical summary: # of words: 5030 # of figures/tables: 6