Altered functional connectivity among frontal eye felds, thalamus and cerebellum in bipolar disorder Adrian Andrzej Chrobak 1 , Bartosz Bohaterewicz 2 , Anna Tereszko 3 , Anna Krupa 4 , Anna Sobczak 2 , Anna Ceglarek 2 , Magdalena Wielgus 2 , Magdalena Fafrowicz 2,5 , Marcin Siwek 6 , Amira Bryll 7 , Tadeusz Marek 2 , Dominika Dudek 1 1 Jagiellonian University Medical College, Department of Adult Psychiatry 2 Jagiellonian University, Department of Cognitive Neuroscience and Neuroergonomics 3 Jagiellonian University Medical College, Chair of Psychiatry 4 University Hospital in Krakow, Department of Adult Psychiatry 5 Malopolska Centre of Biotechnology, Neuroimaging Group, Jagiellonian University 6 Jagiellonian University Medical College, Department of Afective Disorders 7 Jagiellonian University Medical College, Chair of Radiology Summary Objectives: The aim of our study is to evaluate functional connectivity of cerebello- thalamo-cortical networks linking frontal eye felds (FEF) and cerebellar regions associated with oculomotor control: nodulus (X), uvula (IX), focculus (H X) and ventral parafocculus (H IX) in bipolar disorder (BD) with the use of resting state functional magnetic resonance imaging (rsfMRI). Methods: 19 euthymic BD patients and 14 healthy controls underwent rsfMRI examination. Functional connectivity between bilateral FEF, thalamus and cerebellar regions associated with oculomotor control was evaluated. Results: BD patients revealed decreased functional connectivity between following struc- tures: right FEF and bilateral thalamus, focculus (H X), uvula (IX); right thalamus and right FEF; between right focculus (H X) and right FEF, left thalamus; between left thalamus and bilateral FEF and right focculus (H X). Conclusions: BD patients presented decreased functional connectivity among FEF, thala- mus and cerebellar structures associated with eye movements control. Oculomotor evaluation of BD patients assessed with rsfMRI may help to determine whether altered functional con- nectivity observed in our study is associated with eye movements defcits in BD. Key words: vermin, neuroimaging, afective disorders Psychiatr. Pol. 2020; 54(3): 487–497 PL ISSN 0033-2674 (PRINT), ISSN 2391-5854 (ONLINE) www.psychiatriapolska.pl DOI: https://doi.org/10.12740/PP/OnlineFirst/104445