Journal Pre-proofs 3,3-Difluoro-3,4,5,6-tetrahydropyridin-2-amines: potent and permeable BACE-1 inhibitors Aldo Peschiulli, Daniel Oehlrich, Frederik Rombouts, Ann Vos, Harrie JM Gijsen PII: S0960-894X(20)30062-7 DOI: https://doi.org/10.1016/j.bmcl.2020.126999 Reference: BMCL 126999 To appear in: Bioorganic & Medicinal Chemistry Letters Received Date: 12 November 2019 Revised Date: 19 January 2020 Accepted Date: 24 January 2020 Please cite this article as: Peschiulli, A., Oehlrich, D., Rombouts, F., Vos, A., Gijsen, H.J., 3,3-Difluoro-3,4,5,6- tetrahydropyridin-2-amines: potent and permeable BACE-1 inhibitors, Bioorganic & Medicinal Chemistry Letters (2020), doi: https://doi.org/10.1016/j.bmcl.2020.126999 This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. © 2020 Published by Elsevier Ltd.