_____________________________________________________________________________________________________ *Corresponding author: E-mail: drshady78@hotmail.com; International Neuropsychiatric Disease Journal 17(4): 8-17, 2022; Article no.INDJ.89154 ISSN: 2321-7235, NLM ID: 101632319 Early Detection of White Matter Changes with Cognitive Decline in Parkinson's Patients Shimaa Ahmed Ibrahim Elgamal a , Maha Hazem Khalil b , Omar Abd-Elsalam Ahmed b* , Adel Galal El-Badrawy c , Ahmed Esmael b , Shady Khalil El-Rashedy b and Tamer Mohamed Ebrahim Belal b a Department of Neurology, Kafrelshiekh University, Mansoura, Egypt. b Department of Neurology, Mansoura University, Mansoura, Egypt. c Department of Radiology, Mansoura University, Mansoura, Egypt. Authors’ contributions This work was carried out in collaboration among all authors. All authors read and approved the final manuscript. Article Information DOI: 10.9734/INDJ/2022/v17i430208 Open Peer Review History: This journal follows the Advanced Open Peer Review policy. Identity of the Reviewers, Editor(s) and additional Reviewers, peer review comments, different versions of the manuscript, comments of the editors, etc are available here: https://www.sdiarticle5.com/review-history/89154 Received 19 May 2022 Accepted 02 August 2022 Published 08 August 2022 ABSTRACT Objective: The aim of this study was to detect changes in white matter in patients with Parkinson's disease applied by diffusion tensor imaging to predict cognitive impairment. Methods: Montreal cognitive assessment was applied to 50 Parkinson's disease patients to confirm cognitive decline (M: F = 41:9; age: 62.72±9.07 years) and to 20 Parkinson's disease patients with no cognitive impairment as a control (M: F =13:7; age 58.95±11.22). All patients underwent disease severity testing by using Modified Hoehn and Yahr Scale, Unified Parkinson disease rating scale and Diffusion tensor imaging (DTI) for the corpus callosum and cingulum including their involved parts to define affected tracts. Results: In PD with cognitive impairment subjects, the cognitive affection correlated with abnormal DTI parameters of the corpus callosum and cingulum. There were FA or MD differences in both the corpus callosum and cingulum pathways. These findings were independent of age, sex and total white matter volume. Conclusion: Patients with Parkinson's disease associated with cognition decline are detected by tractography changes of the corpus callosum and cingulum. Original Research Article