Copyright@ Dan Vata, Valentin -Tudor Popa | Biomed J Sci & Tech Res | BJSTR. MS.ID.006016. 29507 Research Article ISSN: 2574 -1241 Diagnosis of Psoriasis in Hard-To-Treat Body Locations Ioana-Alina Halip 1 , Dan Vata 1,2 *, Laura Statescu 1,2 , Ioana-Adriana Popescu 1 , Adriana-Ionela Patrascu 2 , Elena Porumb Andrese 1 , Doinita Temelie Olinici 1,2 , Valentin-Tudor Popa 3 * and Laura Solovastru Gheuca 1,2 1 Grigore T Popa University of Medicine and Pharmacy, Faculty of Medicine, Dermatology Department, 16 Universitatii, Romania 2 Dermatology Clinic, St. Spiridon County Emergency Clinical Hospital, Iasi, Romania 3 Victor Babes University of Medicine and Pharmacy, Faculty of Medicine, Dermatology Department, Piața Eftimie Murgu , Romania *Corresponding author: Dan Vata, Grigore T Popa” University of Medicine and Pharmacy, Faculty of Medicine, Dermatology Department, 16 Universitatii, Romania and Valentin -Tudor Popa, Victor Babes” University of Medicine and Pharmacy, Faculty of Medicine, Dermatology Department, Piața Eftimie Murgu, Romania DOI: 10.26717/BJSTR.2021.37.006016 Introduction Inflammatory pathology represented by psoriasis vulgaris is much more than a simple skin condition and is a global health problem. Psoriasis for many patients results in a marked functional, psychological and social morbidity. The concept of psoriasis severity refers to many different aspects of psoriasis, including the extent of the disease, the location of the lesions, the degree of inflammation, the ability to respond to treatment and the impact on quality of life. Thus, patients with any type of psoriasis require an assessment of the severity of the disease, the impact of the disease on physical, psychological and social condition, diagnosis of the existence of psoriatic arthritis or other comorbidities. Overall assessment of the patient, assessment of the affected body surface, nail damage, affected areas with high impact and difficult to treat, or any systemic disorder such as fever, malaise, which are common in unstable forms of psoriasis such as erythroderma or generalized pustular psoriasis [1]. Psoriasis is a chronic, multisystemic disease with many comorbidities, which is often difficult to treat, and some cases may be refractory to treatment. Total eradication of plaques is difficult to achieve, and the remission time is short. Recurrence is inevitable and is often preceded by poor adherence to topical therapy. Forms of gouttate psoriasis may resolve spontaneously or may progress to chronic plaque psoriasis. Erythrodermic psoriasis and generalized ARTICLE INFO ABSTRACT Background: The epidemiological profile of psoriasis may show the great psycho- emotional impact through hard-to-treat body locations. Methods: We performed a retrospective study of 527 patients with psoriasis in the Dermatological Clinic of the Emergency County Clinical Hospital “Saint Spiridonov”, Iasi in order to establish the frequency of major forms of psoriasis and describe the characteristics such as age group and special impairment distribution. Results: The frequency of scalp psoriasis was significantly higher in patients aged ≤18 years (51.61% compared to 32.73% aged 19-49 years, Z=2.01, p=0.02; compared to 31, 66% aged between 50-69 years, Z=2.22, p=0.01 or compared to 29.17% aged ≥ 70 years, Z=2.18, p=0.01). Facial psoriasis was significantly higher in patients aged ≤18 years (12.9% compared to 4.24% aged 19-49 years, Z=1.92, p=0.027, compared to 1.16 % aged between 19-49 years, Z=4.02, p <0.00001 and compared to 1.39% aged ≥ 70 years, Z=2.49, p=0.006). It was also observed that the frequency of genital area involvement was significantly high (38.1%, Z = 1.77, p = 0.038). Conclusion: The burden of disease may be due to high frequency of hard-to- treat body locations such as the facial and scalp regions at early age and genital area involvement has a negative impact on their quality of life. Received: July 14, 2021 Published: July 27, 2021 Citation: Ioana-Alina Halip, Dan Vata, Laura Statescu, Ioana-Adriana Popescu, Valentin -Tudor Popa, et al., Diagnosis of Psoriasis in Hard-To-Treat Body Loca- tions. Biomed J Sci & Tech Res 37(3)-2021. BJSTR. MS.ID.006016. Keywords: Psoriasis; Hard-To-Treat Body Locations; Quality of Life