Available on line www.jocpr.com Journal of Chemical and Pharmaceutical Research __________________________________________________ ISSN No: 0975-7384 CODEN(USA): JCPRC5 J. Chem. Pharm. Res., 2010, 2(6):435-440 435 Antibacterial activity of Plumeria rubra Linn. plant extract 1 Ajay Singh Baghel, 1 Chanchal Kumar Mishra, 2 Asha Rani and 3 D Sasmal and 4 Rajesh Kumar Nema 1 Arya College of Pharmacy, Kukas, Jaipur, Rajasthan 2 Govt. Pharmacy Institute, Bariatu, Ranchi, Jharkhand 3 Dept. of Pharmaceutical Sciences, Birla Institute of Technology, Mesra, Ranchi 4 Rishiraj College of Pharmacy, Indore ______________________________________________________________________________ ABSTRACT A large number of medicinal plants are claimed to be useful in skin disease in all traditional system of medicine and folklore. While these plant remedies are being used orally and by local application. Looking to the scope of herbal drug and increasing demand especially in disease of liver, cancer, diabetes, hypertension, renal disease, inflammation, infectious diseases and skin diseases etc. Plumeria rubra Linn. has been selected because of its easy of availability, therapeutic value and degree of research work which is not done. Plumeria rubra Linn. is a deciduous tree with thick, widely distributed in common rather moist garden, in lawns and in open plantation tree is unusual in appearance. Plant loses leaves for a short time during the winter. Slowly grows up to height 25 feet with 35 spread. About eight species of Plumeria rubra (L.) occurs in India. The ascending branches leave simple Alternate, spiral, elliptic or ovate shape, base tapering (narrow attenuate) or oblique, margins entire or undulate, apex acuminate or acute or obtuse. Pink or red color flowers and flowering period is August to October. According to Ayurveda; root is bitter, carminative, thermogenic, etc. Leaves are useful in inflammation, rheumatism, antibacterial, antifungal, bronchitis, Antipyretic etc. The in vitro antibacterial activity of ethanolic, chloroform, ethyl acetate and aqueous extract of leaves of Plumeria rubra (L.) has been evaluated using disc diffusion method against S. epidermidis and Escherischia coli of bacterial strains. Comparatively, extract showed significant antibacterial activity with specific standard (Ciprofloxacin). Key Words: Plumeria rubra Linn., Antibacterial Activity. _____________________________________________________________________________ INTRODUCTION A large number of medicinal plants are claimed to be useful in skin disease in all traditional system of medicine and folklore. While these plant remedies are being used orally and by local application since ancient, the mechanism whereby such effects elicited has not been looked into. These effects have been brought about by their inherent antibacterial activity by different plants.