Bioresource Technology 333 (2021) 125069 Available online 2 April 2021 0960-8524/© 2021 Elsevier Ltd. All rights reserved. A review targeting veterinary antibiotics removal from livestock manure management systems and future outlook Mohamed S. Gaballah a, b , Jianbin Guo a, * , Hui Sun a , Dominic Aboagye a , Mostafa Sobhi a, c , Atif Muhmood a , Renjie Dong a, d a College of Engineering (Key Laboratory for Clean Renewable Energy Utilization Technology, Ministry of Agriculture), China Agricultural University, Beijing 100083, PR China d Yantai Institute, China Agricultural University, Yantai 264032, Shandong, PR China b National Institute of Oceanography and Fisheries, Cairo, Egypt c Agricultural and Bio-systems Engineering Department, Faculty of Agriculture, Alexandria University, Alexandria, Egypt HIGHLIGHTS G R A P H I C A L ABSTRACT • VAs excretion rate and their variability of contents in different animal manures were reviewed. • VAs release from the animal breeding industry into the surrounding environ- ment has been confrmed. • Biodegradation, adsorption and sorp- tion, and uptake are the main VAs removal pathways. • On-site anaerobic digestion revealed 73% removal of VAs, 84.7% with com- posting, and 90% with Constructed wetlands. • Pre-treatment of manure, proper stor- age, and settling can improve the removal effciency of VAs. A R T I C L E INFO Keywords: Veterinary antibiotics Livestock farms Removal pathways Manure management ABSTRACT Veterinary antibiotics (VAs) contamination has been considered as a worldwide environmental and health concern in recent decades. This paper reviewed the variability of contents of VAs and their release from the animal breeding industry into the surrounding environment along with the performance of the manure treatment technologies. The data collected revealed that VAs were mostly excreted in animal feces and observed in manure, soil, water, and sediment. The fndings illustrate the disparity of VAs in excretion rates, consumption, and their residues in the environment with relatively high distribution for tetracyclines, fuoroquinolones, and sulfon- amides. Anaerobic digestion has a capacity to remove of 73% VAs while manure composting and constructed wetlands can remove 84.7%, and 90% VAs. Due to the profound effect of antibiotics on the environment, further research and intensive management strategies for livestock manure need to be designed to improve the removal effciency and manure management technologies. * Corresponding author at: College of Engineering, China Agricultural University, Beijing 100083, China. E-mail address: jianbinguo@cau.edu.cn (J. Guo). Contents lists available at ScienceDirect Bioresource Technology journal homepage: www.elsevier.com/locate/biortech https://doi.org/10.1016/j.biortech.2021.125069 Received 31 January 2021; Received in revised form 21 March 2021; Accepted 23 March 2021