This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi: 10.1111/APM.13014 This article is protected by copyright. All rights reserved The first wide-scale drug repurposing screen using the Prestwick Chemical Library (1200 bioactive molecules) against Neisseria gonorrhoeae identifies high in vitro activity of auranofin and many additional drugs SUNNIVA FOERSTER 1,2 , TOMAS N. GUSTAFSSON 3 , ANNA RITA BROCHADO 2 , VALENTINO DESILVESTRO 4 , ATHANASIOS TYPAS 2, ** and MAGNUS UNEMO 1 * , ** 1 WHO Collaborating Centre for Gonorrhoea and other STIs, Department of Laboratory Medicine, Faculty of Medicine and Health, Örebro University, Örebro, Sweden; 2 European Molecular Biology Laboratory (EMBL), Genome Biology Unit, Heidelberg, Germany; 3 Department of Clinical Microbiology, Sunderby Research Unit, Umeå University, Umeå, Sweden; 4 World Trade Institute (WTI), University of Bern, Bern, Switzerland **Joint senior authors *Corresponding author: WHO Collaborating Centre for Gonorrhoea and Other Sexually Transmitted Infections, National Reference Laboratory for STIs, Department of Laboratory Medicine, Microbiology, Örebro University Hospital, SE-701 85 Örebro, Sweden. Phone: +46-19- 6022038. Fax: +46-19-127416. e-mail: magnus.unemo@regionorebrolan.se Running head: PRESTWICK CHEMICAL LIBRARY SCREEN FOR GONOCOCCI Word Count: Abstract: 250 words, Main text: 2736 words SUMMARY Foerster S, Gustafsson TN, Brochado AR, Desilvestro V, Typas A, Unemo M. The first wide-scale drug repurposing screen using the Prestwick Chemical Library (1200 bioactive molecules) against Neisseria gonorrhoeae identifies high in vitro activity of auranofin and many additional drugs Accepted Article