Author note: This is a preprint. The final article is published in “The Handbook on Socially Interactive Agents” by ACM books. Citation information: Krämer, N., and Manzeschke A., (2021). Social Reactions to Socially Interactive Agents and Their Ethical Implications. In B. Lugrin, C. Pelachaud, D. Traum (Eds.), Handbook on Socially Interactive Agents – 20 Years of Research on Embodied Conversational Agents, Intelligent Virtual Agents, and Social Robotics, Volume 1: Methods, Behavior, Cognition (pp. 77- 103). ACM books. DOI of the final chapter: 10.1145/3477322.3477326 DOI of volume 1 of the handbook: 10.1145/3477322 Correspondence concerning this chapter should be addressed to Nicole Krämer (nicole.kraemer@uni-due.de) or Arne Manzeschke (arne.manzeschke@evhn.de) Social Reactions to Socially Interactive Agents and Their Ethical Implications Nicole Krämer and Arne Manzeschke