A432 SLEEP, Volume 40, Abstract Supplement, 2017 pro-inflammatory cytokine IL-6 in patients with dementia. Furthermore, extended sleep and sleepiness is a marker of generalized inflammation in demented patients and may be an adverse prognostic sign of coarse of the disease. Finally, from a clinical standpoint, sedative psychotrop- ics to control common symptoms in this population, such as sleep dis- turbances, agitation, hallucinations, should be used with caution. Support (If Any): Thales, University of Crete, A multi-disciplinary network for the study of the Alzheimer’s disease National Strategic Reference Framework (ESPA) 2007–2013 1157 INFLAMMATION IS ASSOCIATED WITH EXCESSIVE DAYTIME SLEEPINESS AND IMPAIRED COGNITIVE PERFORMANCE IN PATIENTS WITH MILD COGNITIVE IMPAIRMENT (MCI) Basta M 1,2 , Koutentaki E 1 , Vogiatzi E 3 , Zaganas I 3 , Panagiotakis S 4 , Kapetanaki S 3 , Anastasaki M 1 , Simos P 1 , Vgontzas A 1,2 1 Department of Psychiatry, University Hospital of Heraklion, HERAKLION, CRETE, GREECE, 2 Sleep Research and Treatment Center, Department of Psychiatry, Penn State University, Hershey, PA, 3 Department of Neurology, University Hospital of Heraklion, HERAKLION, CRETE, GREECE, 4 Department of Internal Medicine, University Hospital of Heraklion, HERAKLION, CRETE, GREECE Introduction: It has been shown that inflammatory markers are elevated in patients with cognitive impairment and are associated with excessive daytime sleepiness (EDS). Furthermore, we have pre- viously shown that extended sleep/sleepiness in patients with Mild Cognitive Impairment (MCI) is associated with impaired cognitive performance. The aim of this study was to assess the associations between inflammation, objective sleep, and cognition among patients with MCI. Methods: A sub-sample of 119 patients with MCI were recruited from a large, population-based cohort in the island of Crete, Greece of 3140 older adults (>60yrs). The goal of this study was to assess the preva- lence and risk factors associated with cognitive impairment. All par- ticipants underwent medical history/physical examination, extensive neuropsychiatric and neuropsychological evaluation, 3-day 24-h actig- raphy and a single morning IL-6 and TNFa plasma level. Associations between (a) inflammatory markers and sleep variables and (b) inflam- matory markers and cognition, were assessed using Linear Regression Analysis controlling for gender, age, BMI and depression for the for- mer, and age, gender, and education, for the later. Results: Peripheral levels of IL-6 were 1.2 ± 0.83 pgr/ml(mean ±SD), and TNFa were 1.18 ± 0.57pgr/ml. Regression analysis found a bor- derline significant association between IL-6 and daytime Total Sleep Time (r=0.186,p=0.07). Furthermore, regression analyses revealed significant associations between IL-6 and a number of episodic mem- ory indices including immediate (β = -0.279, p = 0.003) and delayed word list recall (β = -0.25, p = .013), delayed complex figure reproduc- tion (β = -0.26, p =0 .010), and autobiographic memory (β = -0.25, p =0 .009), and between TNFa and delayed word list recall (β= -0.217, p = -0.028). Conclusion: These data indicate that in patients with MCI, EDS and cognitive impairment are associated with inflammation. It appears that improvement of inflammation through pharmacologic and/or behavio- ral i.e. exercise, interventions may improve the prognosis in patients with MCI. Support (If Any): Thales, University of Crete, A multi-disciplinary network for the study of the Alzheimer’s disease, National Strategic Reference Framework (ESPA) 2007–2013 1158 REDUCED SLEEP SPINDLE ACTIVITY IN PARKINSON’S DISEASE IS ASSOCIATED WITH NEUROPSYCHOLOGICAL IMPAIRMENT Mullins AE 1 , Bolitho SJ 2 , Terpening Z 3 , D’Rozario AL 4 , Kim JW 4 , Melehan KL 6 , Marshall NS 7 , Grunstein RR 4 , Naismith SL 8 , Lewis SJ 9 1 CIRUS, Centre for Sleep and Chronobiology, Woolcock Institute of Medical Research, Sydney, AUSTRALIA, 2 Sydney Medical School, University of Sydney, Sydney, AUSTRALIA, 3 Healthy Brain Ageing Program, Brain and Mind Centre, University of Sydney, Sydney, AUSTRALIA, 4 NeuroSLEEP, NHMRC Centre for Research Excellence, Sydney, AUSTRALIA, 5 NeuroSLEEP, NHMRC Centre for Research Excellence, Sydney, AUSTRALIA, 6 Department of Respiratory and Sleep Medicine, RPAH, Sydney Local Health District, Sydney, AUSTRALIA, 7 Sydney Nursing School, University of Sydney, Sydney, AUSTRALIA, 8 School of Psychology, University of Sydney, Sydney, AUSTRALIA, 9 Parkinson’s Disease Research Clinic, Brain and Mind Centre, University of Sydney, Sydney, AUSTRALIA Introduction: Sleep disturbances and cognitive impairment are sali- ent non-motor features of Parkinson’s disease (PD). Using quantitative EEG (qEEG) measures we investigated whether slow wave and spindle activity during NREM sleep, which are thought to be involved in cog- nitive processing, differed between Parkinson’s disease patients and healthy age-matched controls. Further aims were to consider the effect of dopaminergic medication and REM behaviour disorder (RBD) sta- tus and explore the relationship between sleep qEEG and cognitive task performance in PD. Methods: Thirty-two patients with Parkinson’s disease (10 female; mean age 63.5) and fourteen healthy controls (8 female; mean age 65) underwent overnight polysomnography, neurological and neuropsychological assessment. Spectral power and spindle algorithm analysis during NREM sleep at frontal, central, parietal and occipital sites were compared between the groups. We also evaluated the effect of dopaminergic medication and RBD status and tested associations between qEEG profiles and cognitive per- formance in PD. Results: Patients with Parkinson’s disease showed reduced fast and slow spindle activity in centro-parietal EEG during NREM sleep compared to controls. In PD, reduced spindle activity across the cortex was moderately correlated (Rho 0.35–0.64) with poorer performance on cognitive tasks. Neither treatment with dopamin- ergic medication or diagnosis of RBD altered EEG microstructure significantly. Conclusion: Sleep spindle activity is reduced in Parkinson’s disease and is generally associated with neuropsychological impairment. Spindle activity may be a biomarker of cognitive decline and could provide a prospective marker in the evolution of dementia in PD. Support (If Any): None 1159 SLEEP-RELATED RESPIRATORY ABNORMALITIES DURING SEIZURES Latreille V 1 , Abdennadher M 2 , Dworetzky B 1 , Ramel J 1 , White DP 1 , Katz ES 4 , Zarowski M 5 , Kothare S 6,4 , Pavlova M 1 1 Brigham and Women’s Hospital, Boston, MA, 2 University of Texas, Austin, TX, 3 Brigham and Women’s Hospital, Boston, MA, 4 Children’s Hospital Boston, Boston, MA, 5 Poznan University of Medical Sciences, Poznan, POLAND, 6 NYU Langone Comprehensive Epilepsy Sleep Institute, New York, NY B. Clinical Sleep Science X. Sleep and Neurologic Disorders Downloaded from https://academic.oup.com/sleep/article-abstract/40/suppl_1/A432/3781223 by guest on 30 May 2020