225 Vijay Kumar Takur and Manju Kumari Takur (eds.), Handbook of Polymers for Pharmaceutical Technologies, Volume 3 (225–242) © 2015 Scrivener Publishing LLC *Corresponding author: wongtinwui@salam.uitm.edu.my; wongtinwui@yahoo.com 7 Cellulose-, Ethylene Oxide- and Acrylic-Based Polymers in Assembled Module Technology (Dome Matrix®) Camillo Benetti 1, 2 , Paolo Colombo 1 and Tin Wui Wong* 2,3,4 1 Pharmacy Department, University of Parma, Parma, Italy 2 Non-Destructive Biomedical and Pharmaceutical Research Centre 3 Particle Design Research Group, Faculty of Pharmacy, Universiti Teknologi MARA, Selangor, Malaysia 4 Pharmaceutical and Life Science, Universiti Teknologi MARA, Selangor, Malaysia Abstract Dome Matrix  is an innovative drug delivery platform based on polymeric matrices or modules, designed to allow the assembly of two or more modules in one modular assembled system. As such, diferent drugs in the assembled system can be administered orally at the same time, at diferent doses and release rates or in a selected site of gastrointestinal tract by means of a single Dome Matrix system. Te Dome Matrix is an assembly of modules that have one concave face and one convex face. A female unit has a cylindrical protrusion on the convex face that can be ftted into the concave face of another female unit, while a male unit is characterized by an annular protrusion on the convex face that can be ftted into the concave face of a female unit. Several polymers have been employed in the design of Dome Matrix, namely derivatives of cel- lulose, acrylic acid polymers, polymethacrylates and polyethylene oxide. Tis review highlights the polymer properties and formulation outcomes with the aim of producing inert or swellable matrix that acts to sustain or promote drug release. Keywords: Acrylic acid polymers, cellulose derivatives, Dome Matrix, polyethylene oxide, polymethacrylates 7.1 Dome Matrix  Technology With the advances in pharmacogenomic and pharmacogenetic sciences, individu- alized therapy is met with challenges of having dosage form that can be mixed and matched to meet the intended drug regimen and pharmacokinetics requirements. In 2006, Colombo et al. devised an innovative modular technology platform where the single-unit dosage form design can be modulated through the assembly of the required