CONCLUSION Compared with western, Korean patients had different warfarin genetic frequencies. Multiple genes (VKORC1, CYP2C9 and CYP4F2 gene) influenced the stability of maintenance phase warfarin dosage. VKORC1 gene was the most important factor affecting the warfarin dose. TCTAP A-085 A Clinical Study of Risk Factor Profile Especially with Reference to Diabetes in Patients Presenting with Angina and Showing Normal Coronaries Raghu Kishore Galla, 1 Maddury Jyotsna, 1 Lalita Nemani, 1 Rama Krishna Janapati, 2 Indrani Garre, 1 Janaswamy Vibhav Sri Narayana 3 1 Nizam’s Institute of Medical Sciences, India; 2 Citizens Hospital, India; 3 Osmania Medical College, India BACKGROUND To look for the frequency of occurrence of traditional and other non-traditional risk factors, biochemical parameters and complications in both diabetics and non-diabetic patients showing normal coronaries on CAG. METHODS We evaluated 856 consecutive patients presenting with angina and undergoing coronary angiogram yielded normal CAG be- tween June 2015 to March 2017 at our center. We obtained the detailed risk factor, clinical and biochemical profile from the records, analyzed the occurrence of other risk factors in diabetic and non-diabetic sub- groups and tested for any statistical significance using Minitab v17 software. RESULTS Of the total 856 patients 409 (47.7%) were males, 435 (50.8%) had Hypertension, 232 (27.1%) had DM, 89 (10.3%) were smokers, 27 (3.1%) had family history of CAD, 104 (12.1%) had LV dysfunction. Normal coronaries in CAG is more common in females than males in both diabetic (56.8%) and non-diabetic (50.4%) but there is no statistical significance (p¼0.08). Mean age is 52.72 Æ 11.00 in diabetics vs 50.82 Æ 11.38 in non-diabetics which is significant (p¼0.02). Occurrence of HTN is significantly more in patients with diabetes than non-diabetics (p¼0.00). There is no significant differ- ence in occurrence of family history (p¼0.12), smoking (p¼0.8), LV dysfunction (p¼0.8), Renal dysfunction (p¼0.07) between these two subgroups. CONCLUSION In patients presenting with angina and showing normal coronaries in CAG only 27.1% had diabetes. The occurrence of normal CAG is more common in female patients in both diabetic and non- diabetics. Diabetic patients are more aged and more frequently had hypertension than non-diabetics which are statistically significant. There is no significant difference in family history, smoking, and occurrence of LV dysfunction or renal dysfunction in this two sub- groups. TCTAP A-086 Salvage of Venous Rupture by Stent Graft During Percutaneous Intervention of Dialysis Vascular Access Ming-Chien Hsieh, 1 Pei-Shan Lin, 1 Chih-Kuo Lee, 1 Chih-Cheng Wu 1 1 National Taiwan University Hospital, Taiwan BACKGROUND Percutaneous transluminal angioplasty (PTA) -induced venous rupture is a common complication of hemodialysis access intervention. Various management strategies have been reported but the patency outcome was poor. We aim to report the im- mediate and patency results with a self-expandable stent graft for salvage of PTA-induced venous rupture during hemodialysis access intervention. METHODS In our institution, the VIAHBAN stent grafts were used to treat procedure-related vessel rupture since 2013. The decision of strategies to salvage venous rupture was dependent on the discretion of individual operators. Data were retrospectively extracted from a prospectively-collected database of percutaneous interventions for hemodialysis vascular access from 2013 to 2016. RESULTS From our database, 33 patients were treated with the stent- grafts for vessel rupture. Twelve patients had arteriovenous (AV) fis- tulas and 21 had AV grafts. Twenty of the vessel ruptures occurred during thrombectomy procedures. Location of rupture was the outflow venous segment (n¼22), cephalic arch (n¼8), and intra-graft (n¼1). Technical success was achieved in all procedures (100%) and all extravasation was halted with preservation of vascular access. In two patients, recurrent thrombosis developed before the coming dialysis session and the clinical success rate was 94%. There was no compli- cation related to the stent graft placement. Only seven patients experienced target lesion restenosis at six months. The primary patency rate of vascular access was 39% at six months. One access failed in six months and the secondary patency rate was 97%. CONCLUSION Stent graft successfully salvaged procedure-induced vessel rupture with a low target lesion restenosis rate at six months. The primary patency rate of the whole access was compromised by a high incidence of recurrent thrombosis or non-target lesion rest- enosis. TCTAP A-087 Normal Coronary Arteries and Its Two Years Outcomes Indrani Garre, 1 Maddury Jyotsna, 1 Nallagasu Raju, 1 Lalita Nemani, 1 Sree Bhushan Raju 1 1 Nizam’s Institute of Medical Sciences, India BACKGROUND Heart disease is the leading cause of death in the world, and coronary angiography is the standard instant test for detection of critical diseases. The accuracy of angiography has been questioned for long. Investigations with intra-vascular ultrasound show high-risk lesions in many vessels with no apparent disease seen via standard angiography; these lesions are at risk of rupture and acute thrombus formation despite negligible luminal stenosis. False- negative angiograms could lead to under-treatment of modifiable risk factors or failure to protect patients with coronary heart disease (CHD) from life-threatening cardiac events. Among patients who had a JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, VOL. 71, NO. 16, SUPPL S, 2018 S47