Int. J. Curr. Res. Chem. Pharm. Sci. (2024). 11(2): 41-51 © 2024, IJCRCPS. All Rights Reserved 41 INTERNATIONAL JOURNAL OF CURRENT RESEARCH IN CHEMISTRY AND PHARMACEUTICAL SCIENCES (p-ISSN: 2348-5213: e-ISSN: 2348-5221) www.ijcrcps.com (A Peer Reviewed, Referred, Indexed and Open Access Journal) DOI: 10.22192/ijcrcps Coden: IJCROO(USA) Volume 11, Issue 2- 2024 Review Article Nutritional Strategies for Enhancing Immune Resilience in HIV: A Review * Emmanuel Ifeanyi Obeagu 1 , Nwanganga Ihuoma Ubosi 2 , Getrude Uzoma Obeagu 3 and Angela Amarachi Obeagu 4 1 Department of Medical Laboratory Science, Kampala International University, Uganda. 2 Department of Public Health Sciences, Faculty of Health Sciences, National Open University of Nigeria, Headquarters, Jabi, Abuja, Nigeria. 3 School of Nursing Science, Kampala International University, Uganda. 4 Department of Human Nutrition and Dietetics, Michael Okpara University of Agriculture, Umudike, Abia State, Nigeria. * Corresponding authour: Emmanuel Ifeanyi Obeagu, Department of Medical Laboratory Science, Kampala International University, Uganda, emmanuelobeagu@yahoo.com, ORCID: 0000-0002-4538-0161 Abstract Human Immunodeficiency Virus (HIV) remains a global health concern, necessitating multifaceted approaches to improve patient outcomes. While antiretroviral therapy (ART) has significantly transformed HIV management, there is a growing recognition of the role of nutritional support in enhancing immune resilience among affected individuals. This comprehensive review explores the current scientific understanding of nutritional strategies aimed at fortifying the immune system in the context of HIV. Key micronutrients, such as vitamin D, zinc, and selenium, are investigated for their potential in mitigating immune dysfunction. Probiotics are discussed as a means to modulate gut health and address gut-associated immune issues prevalent in HIV. Additionally, the review delves into the immunomodulatory effects of dietary supplements, including omega-3 fatty acids and glutamine. The role of nutrient-rich foods, such as fruits, vegetables, and lean proteins, is explored in supporting immune resilience. Practical challenges associated with implementing nutritional interventions in HIV management, including adherence and potential interactions with medications, are considered. Looking forward, the review discusses emerging trends and future directions in the field, such as personalized nutrition and collaborative healthcare approaches. Ultimately, the integration of nutritional support alongside conventional HIV care holds promises for improving immune resilience, thereby contributing to enhanced overall health outcomes for individuals living with HIV. Keywords: HIV, Immune Resilience, Nutritional Support, Antiretroviral Therapy, Micronutrients, Probiotics, Immunomodulation, Immune Boosting Foods DOI: http://dx.doi.org/10.22192/ijcrcps.2024.11.02.005