Open Access Maced J Med Sci. 2021 Sep 20; 9(B):1229-1236. 1229 Scientifc Foundation SPIROSKI, Skopje, Republic of Macedonia Open Access Macedonian Journal of Medical Sciences. 2021 Sep 20; 9(B):1229-1236. https://doi.org/10.3889/oamjms.2021.7027 eISSN: 1857-9655 Category: B - Clinical Sciences Section: Cardiology Lipid Accumulation Product as an Index for Visceral Obesity and Cardiovascular Risk among a Sample of Obese Egyptian Women Nayera E. Hassan 1 , Sahar A. El-Masry 1 * , Gamila S. M. El-Saeed 2 , Mohamed S. El Hussieny 1 1 Department of Biological Anthropology, Medical Research Division, National Research Centre, Dokki, Giza, Egypt; 2 Department of Medical Biochemistry, Medical Research Division, National Research Centre, Cairo, Egypt Abstract BACKGROUND: Lipid accumulation product (LAP) is one of the indices that can demonstrate cardiovascular risk factors according to international studies. AIM: The aim of the study was to evaluate relationship between LAP, visceral obesity, and diferent cardio vascular risk factors among sample of obese Egyptian Women. METHODS: A retrospective cross-sectional observational study included 350 obese Egyptian women; aged 25–55 years. They were subjected to blood pressure (BP) and anthropometric assessment (weight, height, and waist circumference [WC]), abdominal ultrasound (visceral fat), and laboratory tests (fasting blood sugar and lipid profle). RESULTS: The majority of the participated women had wide WC (88.9%) and increased visceral fat (80.6%). Hyperglycemia was present among (47.4%), hypertension among 42.6%, high triglycerides among 26.6%, and low high-density lipoprotein among 44.3%. The odds of obtaining LAP >80.74 cm.mmol/L (4 th quartile) are 2.7 times higher in individuals with hypertension (blood BP >130/85), and 6.79 times higher in individuals with visceral fat ≥5 cm. Depending on the visceral fat as a standard for classifcation of visceral obesity (>5 cm for women), revealed that the area under the curve of LAP was 0.752 (95% Confdence interval 0.697–0.806) in women. The cutof point of LAP; for prediction of visceral obesity among Egyptian women, was 61.69; using receiver operating characteristic analysis; with sensitivity 68% and specifcity 75% and positive predictive value/negative predictive value 1.05 and accuracy 71.5%. CONCLUSION: LAP index had signifcant correlations with visceral obesity and hypertension. The cutof point of LAP 61.69 can be used to predict visceral obesity among Egyptian women. Edited by: Mirko Spiroski Citation: Hassan NE, El-Masry SA, El-Saeed GSM, El Hussieny MS. Lipid Accumulation Product as an Index forVisceral Obesity and Cardiovascular Risk among a Sample of Obese Egyptian Women. OpenAccess Maced J Med Sci. 2021 Sep 20; 9(B):1229-1236. https://doi.org/10.3889/oamjms.2021.7027 Keywords: Lipid accumulation product; Visceral fat; Cardiovascular risk factors; Egyptian women *Correspondence: Sahar A. El-Masry, Department of Biological Anthropology, National Research Centre, 33 El-Bohooth St., Dokki, Giza, Cairo 12622, Egypt. E-mail: masrysa@yahoo.com Received: 04-Aug-2021 Revised: 08-Sep-2021 Accepted: 10-Sep-2021 Copyright: © 2021 Nayera E. Hassan, Sahar A. El-Masry, Gamila S. M. El-Saeed, Mohamed S. El Hussieny Funding: This research did not receive any fnancial support Competing Interest: The authors have declared that no competing interest exists Open Access: This is an open-access article distributed under the terms of the Creative Commons Attribution- NonCommercial 4.0 International License (CC BY-NC 4.0) Introduction Obesity is the ffth leading cause of death worldwide. It is a documented risk factor for large number of metabolic abnormalities as insulin resistance, dyslipidemia, higher levels of blood pressure (BP), and cardiovascular diseases (CVD) [1]. Approximately 80% of all body fat is distributed subcutaneously, accumulated largely at gluteo-femoral regions, at the back and at anterior abdominal wall. The visceral fat represents only 10–20% of the total amount of fat in male and 5–8% in females [2]. Abdominal obesity, in particularly high visceral fat, plays a crucial role in the evolution of metabolic and CVD independent of generalized obesity [3]. Multiple anthropometric measurements are used regularly for assessment of obesity such as body mass index (BMI), waist circumference (WC), and waist-to-hip ratio, but most of them cannot distinguish between visceral fat and subcutaneous fat [4]. Recently, mathematically calculated indices have been considered reliable and efective [5]. These methods are considered more applicable options, as they include formulas and biochemical measures that enable medical practice and research to enquire better tracking and risk factors prevention [6]. Lipid accumulation product (LAP) is one of these indices. It is described in the literature as sensitive and specifc markers for assessment of visceral fat compared to other traditional parameters including WC and BMI. It is calculated as a combination of WC and fasting triglyceride (TG). Its superiority is the simultaneous refection of the anatomical and physiological changes of fat over accumulation in adults. According to international studies, LAP can demonstrate risk factors associated with CVD fairly well [7]. In clinical practice, imaging modalities including computed tomography (CT) and magnetic resonance imaging are considered the gold standards for assessment of visceral and subcutaneous fat. Their high costs and radiation exposure in case of CT enormously limit their widely use in medical feld. Therefore, it is crucial to establish a simple and efective method for the assessment of visceral obesity in adults [8].