Substance Use Disorders Alicia Kowalchuk, Sandra J. Gonzalez, Maria C. Mejia, and Roger J. Zoorob Contents Definition and Background .............................................................. 2 SUD History and Primary Care ......................................................... 2 Epidemiology .............................................................................. 3 Classification .............................................................................. 3 DSM-5 Criteria for Substance Use Disorders .......................................... 3 DSM-5 Diagnostic Criteria for Substance Use Disorders ............................. 4 General Principles ........................................................................ 5 Approach to the Patient .................................................................. 5 Screening, Brief Intervention, and Referral to Treatment ............................ 5 Office-Based Opioid Treatment .......................................................... 5 Diagnosis ................................................................................... 6 History ...................................................................................... 6 Physical Examination ..................................................................... 7 Laboratory and Imaging ................................................................. 7 Imaging .................................................................................... 8 Genetic Testing ............................................................................ 8 A. Kowalchuk (*) · S. J. Gonzalez · M. C. Mejia · R. J. Zoorob Department of Family and Community Medicine, Baylor College of Medicine, Houston, TX, USA e-mail: aliciak@bcm.edu; Sandra.Gonzalez@bcm.edu; Maria.Mejia@bcm.edu; roger.zoorob@bcm.edu © Springer Science+Business Media LLC 2020 P. Paulman et al. (eds.), Family Medicine, https://doi.org/10.1007/978-1-4939-0779-3_174-1 1