_____________________________________________________________________________________________________ ≡ Reader; ⱷ Senior Lecturer; *Corresponding author: E-mail: jayalakshmisomasundaram@saveetha.com; Journal of Pharmaceutical Research International 34(6B): 31-39, 2022; Article no.JPRI.79239 ISSN: 2456-9119 (Past name: British Journal of Pharmaceutical Research, Past ISSN: 2231-2919, NLM ID: 101631759) Comparison of Surface Roughness of Two Commercially Available Glass Ionomer Cements after Brushing Simulation with Herbal and Fluoridated Toothpaste - An In vitro Study S. Obuli Ganesh Kishore a , S. Jayalakshmi b*≡ and S. Balaji Ganesh bⱷ a Saveetha Dental College and Hospital, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai - 600077, India. b White lab - Material Research Centre, Saveetha Dental College and Hospital, Saveetha Institute of Medical &Technical Sciences (SIMATS), Saveetha University, Chennai - 600077, India. Authors’ contributions This work was carried out in collaboration among all authors. Authors SOGK, SBG and SJ designed the study, performed the statistical analysis, wrote the protocol and wrote the first draft of the manuscript. Authors SOGK and SBG, managed the analyses of the study. Author SOK managed the literature searches. All authors read and approved the final manuscript. Article Information DOI: 10.9734/JPRI/2022/v34i6B35435 Open Peer Review History: This journal follows the Advanced Open Peer Review policy. Identity of the Reviewers, Editor(s) and additional Reviewers, peer review comments, different versions of the manuscript, comments of the editors, etc are available here: https://www.sdiarticle5.com/review-history/79239 Received 10 November 2021 Accepted 15 January 2022 Published 30 January 2022 ABSTRACT Introduction: Glass ionomer cement is a restorative material used in dentistry as a filling material and luting cement. Nowadays many consumers have started using natural toothpaste in order to avoid synthetic and artificial products. The aim of this study is to compare the surface roughness of two commercially available glass ionomer cements after subjecting them to brushing simulation with herbal and fluoridated toothpaste. Materials and Methods: Glass ionomer cements of two different brands (D- tech and gold label) were moulded into small discs of custom sizes. Their surface roughness before subjecting them to brushing simulation was recorded using Mitutoyo SJ 310 stylus profilometer. Then the glass ionomer cement pellets were mounted on die stones. 4 samples of D-tech and 4 samples of gold label were taken. The mounted samples were placed in a tooth brush simulator (ZM3.8 SD Original Research Article