PENATALAKSANAAN ANESTESIA PADA PASIEN CRETIN DENGAN HIPOPITUITARISME SEKUNDER AKIBAT KRANIOFARINGIOMA ANESTHESIA MANAGEMENT IN CRETIN PATIENT WITH HYPOPITUTARISM SECONDARY OF CRANIOPHARYNGIOMA Theresia Monica Rahardjo, Iwan Fuadi, Tatang Bisri Bagian Anestesiologi dan Terapi Intensif Fakultas Kedokteran, Universitas Padjadjaran, Rumah Sakit Hasan Sadikin Bandung Abstract Craniopharyngioma is a sellar and parasellar tumor, which accounts to 6-10% of childhood brain tumors. Common symptoms are signs of increase intracranial pressure, like headache, vomiting and visual dysfunction. A significant endocrine dysfunction is an usual feature of craniopharyngioma due to the proximity of the tumor to hypothalamus and pituitary gland. Short statue found in 50-86% patient with subnormal growth rates and delayed puberty. A male, 20 yrs cretin patient with hypopituitarism secondary of craniopharyngioma had a craniotomy tumor removal and placement of omaya shunt. He had a history of headache since 13 yrs ago accompanied by visual disturbance, started from his left eye, now he is totally blind. He also suffered from growth failure and delayed puberty, has a physic of a boy regardless his age as 20 yrs old adult, with height 140 cm and weight 40 kg. He has an elevated TSHs but normal T3 and fT4, a decreased LH and FSH, a normal prolactin, a normal but low growth hormon and a decreased cortisol. Anesthetic technique used was general anesthesia. Induction was done with fentanyl, pentotal, lidocaine and vecuronium with a mixture of N 2 O/O 2 and isoflurane. Anesthesia was maintained with isoflurane and a mixture of O 2 /air. Patient was in controlled breathing with an incremental dose of vecuronium to maintaine the relaxation. Mannitol and furosemide were given to reduce intracranial pressure. The procedure took about 5 hours. After 5 days ICU stayed, the patient was referred back to his room at Kemuning. The problems in this patient are a raised of intracranial pressure, an endocrine dysfunction and a possibility of airway difficulty related to his short statue. Corticosteroid as hormone replacement therapy was given before the operation. Based on his short statue, induction dose of anesthetic agents were adjusted and smaller laryngoscope blade and endotracheal tube were used for intubation. Avoidance of nitrous oxide, low concentration of volatile agent and dominant used of intravenous anesthetic agent were applied during the operation. Post operative monitoring was done in ICU with specific concern of hormone complications like diabetes insipidus and hyponatremia beside post operative pain control. Patient with pituitary disease, in this case craniopharyngioma, accompanied by endocrine dysfunction and abnormal growth, need a very careful treatment from preoperative, intraoperative to postoperative period. A good management and cooperation between anesthesiologist, surgeon and endocrinologist can reduce the morbidity and mortality in this kind of disease. Key word : cretin, hypopituitarism, craniopharyngioma JNI 2102;1(3):197-202 Abstrak Kraniofaringioma adalah tumor sela dan parasela, yang merupakan 6-10% tumor otak pada anak-anak. Gejala umum merupakan tanda peningkatan tekanan intrakranial, seperti sakit kepala, muntah dan gangguan penglihatan. Disfungsi endokrin yang nyata merupakan gambaran umum kraniofaringioma akibat lokasi tumor terhadap kelenjar hipotalamus dan pituitari. Fisik pendek ditemukan pada 50-86% pasien dengan laju pertumbuhan subnormal dan pubertas yang terlambat. Seorang laki-laki, umur 20 tahun, pasien kretin dengan hipopituitarisme sekunder menjalani craniotomy tumor removal dan penempatan omaya shunt. Dia memiliki riwayat sakit kepala sejak 13 tahun yang lalu disertai dengan gangguan penglihatan yang dimulai dari mata kiri dan saat ini dia buta. Dia juga menderita kegagalan pertumbuhan dan pubertas yang terhambat, memiliki fisik seorang anak laki-laki, dengan tinggi badan 140 cm dan berat badan 40 kg. Dia memiliki TSHs yang meningkat dengan T3 dan fT4 yang normal, LH dan FSH yang menurun, prolaktin yang normal, hormon pertumbuhan yang normal rendah dan kortisol yang menurun. Teknik