© 2017 Asmaa M. Fahim. This open access article is distributed under a Creative Commons Attribution (CC-BY) 3.0 license. OnLine Journal of Biological Sciences Original Research Paper Microwave Assisted Regioselective Synthesis and Biological Evaluation of Pyrano[2,3-c]Pyridine Derivatives Utilizing DMAP as a Catalyst Asmaa M. Fahim Department of Green Chemistry, National Research Center, Dokki, P.O. Box.12622 Cairo, Egypt Article history Received: 02-10-2017 Revised: 06-12-2017 Accepted: 14-12-2017 E-mail: asmaamahmoud8521@hotmail.com asmaamahmoud8521@gmail.com Abstract: Regioselective facile production of pyrano[2,3-c]pyridine through multicomponent reaction of aromatic aldehydes, ethyl cyano acetate or malononitrile and C-H activated compound of 3-hydroxy picolinic acid in the occurrence of smaller amount of DMAP catalyst utilizing microwave apparatus, which is green and simple environmentally with high yield, recyclability catalyst. Totally the products were partitioned for antimicrobiogical action; it was detected that were active in contrast to S. pneumonia, E. coli and Candida albicans such as equated to typical drugs. Compounds of pyrano[2,3-c]pyridine-8-carboxylic acid derivatives 4i, 4e, 4p and 4p demonstrated effective development inhibitory activities. Additionally, the manufactured products were partitioned for in vitro- antioxidant action by DPPH analysis. Products of pyrano[2,3-c]pyridine 4o and 4p were worthy free radical scavenging action through IC 50 values of 252.52 and 223.2 µM; respectively. Keywords: Multicomponent Reactions (MCR), 4-Dimethylaminopyridine (DMAP), Pyrano[2,3-c]Pyridine, Antimicrobial and Antioxidant Activity Introduction Multicomponent Reactions (MCR) have attempted extensive thought in combinatorial and biological chemistry (Thomas, 2017; Zhu, 2003; Zhu and Bienayme, 2005; Dömling, 2006; Dömling and Ugi, 2000). We established successfully numerous catalytic agent in organic synthesis exhausting MCR approach (Karnakar et al., 2015). The catalyst attractiveness is decrease of solvents ratios (Khan et al., 2008; 2010a; Khan 2010b and Khan, 2011) and furthermore performance role in the yield of the product. This would be inexpensive, mild and environmentally friendly for attention to the synthetic organic researcher. Dimethyl Amino Pyridine (DMAP) is a catalyst of outstanding effectiveness in a variation group-transfer reactions and considered for applications in stereo selective catalysis (Armand et al., 2014). Pyrane and fused 4H-pyrane derivatives have concerned of interest (Dean, 1963) outstanding to their varied physiological activities. (Feuer, 1974) Earlier studies have presented that pyran derivatives possess pronounced chemical and biological activities, such antimicrobial activity, (Bonsignore et al., 1993; Ashraf, 2012) anti-coagulant, (Akbar et al., 2015; Dinesh et al., 2017) anti-tumor and anti-HIV. Additionally, their besides valuable for the neurodegenerative disorder behavior, for instance Alzheimer, lateral amyotrophic sclerosis, Huntington's and Parkinson diseases (Fan et al., 2010) Moreover, they are similarly used as cosmetics, (Vyas et al., 2009) pigments, doze and useful as photoactive fabric (Nandakumar et al., 2010). In recent times, a limited approaches have been informed by hiring three-constituent responses exhausting different catalyst like as DBU (1,8-Diazabicyclo[5.4.0]undec-7- ene) (Wen et al., 2001), TBAB(Tetra-n-butylammonium bromide) (Yusuke et al., 2016), ammonium phosphate (Saeed et al., 2015; 2007; Jitender and Ankita, 2012) hetero-poly supermans (Brahmachari et al., 2014). However, these procedures informed through, others are relatively beneficial, stable, there is auxiliary opportunity to improve innovative approach exhausting inexpensive catalyst above mild reaction stipulation and appropriate to a widespread variety of substrates. Materials and Methods General Instruments Gallenkamp melting point apparatus were used for measuring the melting points. Furthermore the instrument