Karatekin et al. J Otolaryngol Rhinol 2020, 6:076 Citaton: Karatekin D, Ünsal S, Kurtaran H (2020) Evaluaton of Vestbular Evoked Myogenic Potentals Test in Vitamin B12 Defciency. J Otolaryngol Rhinol 6:076. doi.org/10.23937/2572-4193.1510076 Accepted: April 13, 2020: Published: April 15, 2020 Copyright: © 2020 Karatekin D, et al. This is an open-access artcle distributed under the terms of the Creatve Commons Atributon License, which permits unrestricted use, distributon, and reproducton in any medium, provided the original author and source are credited. Journal of Otolaryngology and Rhinology • Page 1 of 4 • Karatekin et al. J Otolaryngol Rhinol 2020, 6:076 ISSN: 2572-4193 Volume 6 | Issue 2 DOI: 10.23937/2572-4193.1510076 Open Access Evaluaton of Vestbular Evoked Myogenic Potentals Test in Vitamin B12 Defciency Deniz Karatekin 1 , Selim Ünsal 2* and Hanif Kurtaran 3 1 Hearing Center, Bursa, Turkey 2 Department of Speech and Language Pathology, Faculty of Health Sciences, İstanbul Atlas University, İstanbul Turkey 3 Department of Otolaryngology Head and Neck Surgery, Special Veni Vidi Eye Health Center, Ankara, Turkey *Corresponding author: Dr. Selim Ünsal, Department of Speech and Language Pathology, Faculty of Health Sciences, İstanbul Atlas University, Vadi Kampüsü Anadolu Cad. No. 40 Kağıthane İstanbul, 444-34-39 İstanbul, 34010, Turkey, Tel: +90-553-593-85-36 Abstract Objective: The aim of this study is to evaluate the possible cervical-vestibular-evoked myogenic potential (C-VEMP) abnormalities in patients with vitamin B12 defciency. Material and method: 35 people with vitamin B12 defcien- cy (16 female, 19 male), 35 people with a normal B12 level who has no hearing or balance problems (18 female, 17 men) participated in the study. Using the 500 Hz stimulus ToneBurst of the patients participated in the study, P1 and N1 wave latencies and amplitudes were evaluated. Results: No statistically signifcant difference was found between P1 and N1 wave latencies and amplitudes at the 500 Hz and 100 dBnHL intensity level of the participants (p < 0.05). Conclusion: Although Vitamin B12 defciency affected the central nervous system, normal fndings were obtained in C-VEMP testing. In vitamin B12 defciency, the saccular, in- ferior vestibular nerve, lateral vestibular nucleus and medial vestibular pathway are not affected. Keywords Vitamin B12, C-VEMP, Vestibular system ReSeaRch aRticle Check for updates Lately, vitamin B12 defciency triggered hyperhomo- cysteinemia has been shown to be signifcantly asso- ciated with neurodegeneratve diseases, cognitve im- pairments, auditory dysfuncton, and neuropsychiatric symptoms [5]. Vitamin B12 defciency has been shown to afect the peripheral vestbular system in some studies [6,7]. The studies on which both peripheral and the central sys- tem are not be found in the literature. One of the electrophysiological measurement method C-VEMP saccule is the short latency electro- myogram record with electrodes of the sternoclei- domastoid (SCM) contracted high intensity click and Tone Burst stimulus through medial vestibular, infe- rior vestibular nerve, lateral vestibular nuclei’s [8,9]. The purpose of this study is to evaluate the functions of the medialvestibular, inferiorvestibular nerve, lat- eralvestibular nucleus path on adults with vitamin B12 deficiency. Materials and Methods This study was conducted in the Audiology and Speech Disorders clinic of Turgut Özal University Medical Faculty Hospital. Ethical approval was ob- tained with the decision of TurgutÖzal University Non-Pharmaceutical Clinical Research Ethics Commit- tee dated 26/09/2014 and numbered 99950669/289. “Volunteer Consent Form” was signed to individuals who participated in the study. 35 people with vitamin Introducton In vitamin B12 defciency, the functon of nerve cells can be disrupted. Vitamin B12 is responsible for balanc- ing neural actvity. B12 is an essental cofactor for the methylaton of proteins of myelin and cells membrane. In vitamin B12 defciency; related to demyelizaton, ax- onal degeneraton and death of neurons, neurological problems emerge [1-4].