International Journal of Medical Science and Public Health | 2016 | Vol 5 | Issue 08 1683 Access this article online Website: http://www.ijmsph.com Quick Response Code: DOI: 10.5455/ijmsph.2016.05122015286 Research Article Storage red blood cell (RBC) transfusion (prime) for extracorporeal circulation circuit in pediatric cardiac surgery: postoperative impact on biochemical changes Atul Solanki 1 , Ramesh Patel 2 , Jigar Patel 2 , Himanshu Acharya 3 , Jignesh Patel 1 , Dhaval Shukla 1 1 Department of Perfusion, UN Mehta Institute of Cardiology and Research Center, (Affliated to BJ Medical College), Ahmedabad, Gujarat, India. 2 Department of Cardiac Anesthesia, UN Mehta Institute of Cardiology and Research Center, (Affliated to BJ Medical College), Ahmedabad, Gujarat, India. 3 Department of Research, UN Mehta Institute of Cardiology and Research Center, (Affliated to BJ Medical College), Ahmedabad, Gujarat, India. Correspondence to: Atul Solanki, E-mail: atulsolanki2001@yahoo.co.in Received December 5, 2015. Accepted December 16, 2015 Background: In neonates, approximately 20% of red blood cell (RBC) and most of the plasma products are used for surgical procedures. The major reason for transfusion in cardiac surgery is because the extracorporeal circulation circuit (ECC) needs to be primed with blood. Biochemical changes take place when RBCs are kept for a phase of time and are together termed the storage lesion. Objective: To clarify the incidence and nature of postoperative liver function, sepsis, and renal function associated with storage RBC prime for cardiopulmonary bypass circuit in new born, infants, and small children. Materials and Methods: A total of 50 consecutive patients who underwent ECC between January 2014 and September 2015 and required blood prime were included in this study. Patients who required RBC were divided into two groups based on patients age and storage RBC age. Arterial blood sample and storage RBCs bag samples were collected in vivo for the assessment for postoperative biochemical parameters determinations. Result: Postoperative white blood cell for >7-day storage RBCs prime in >365 days age patients is 16982.5 ± 4808.45. Postoperative serum glutamic pyruvic transaminase (SGPT) for >7-day storage RBCs prime in >365 days age patients mean (± SD) was 23.5 ± 7.56. Postoperative serum glutamic oxaloacetic transaminase (SGOT) for >7-day storage RBCs prime in >365 days age patients was 139.88 ± 70.32. Postoperative serum bilirubin for >7-day storage RBCs prime in >365 days age patients was 2.13 ± 0.99. Postoperative urea for >7-day storage RBCs prime in >365 days age patients was 25.88 ± 6.73. Postoperative serum creatinine for >7-day storage RBCs prime in >365 days age patients was 0 ± 0. Conclusion: The age of storage RBCs and age of patient results in increased postoperative patients’ white blood counts, SGPT, SGOT, serum creatinine, and blood urea. KEY WORDS: Storage RBCs, extracorporeal circuit, white blood counts, SGPT, SGOT, serum creatinine, blood urea Abstract International Journal of Medical Science and Public Health Online 2016. © 2016 Atul Solanki. This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material for any purpose, even commercially, provided the original work is properly cited and states its license. Introduction The cardiopulmonary bypass (CPB) circuits available presently still need a large priming volume, and it may be greater than the total blood volume of neonates and patient and institutional practices. Presently, banked packed red blood cells (PRBCs) preserved in storage media are assigned for preparing the CPB circuit in infants and children to main- tain the temperature-appropriate hematocrit levels, to prevent