Panacea Journal of Medical Sciences 2023;13(2):352–356 Content available at: https://www.ipinnovative.com/open-access-journals Panacea Journal of Medical Sciences Journal homepage: http://www.pjms.in/ Original Research Article COVID-19 vaccination status and treatment outcome: An observational study in a dedicated COVID Hospital of North East India Bidhan Goswami 1 , Biswajit Sutradhar 2 , Shauli Sengupta 3 , Himadri Bhattacharjya 4, *, Bhaskar Bhattacharjee 3 1 Dept. of Microbiology, Agartala Government Medical College, Agartala, Tripura, India 2 Dept. of Anaesthesiology, Agartala Government Medical College, Agartala, Tripura, India 3 Agartala Government Medical College, Agartala, Tripura, India 4 Dept. of Community Medicine, Agartala Government Medical College, Agartala, Tripura, India ARTICLE INFO Article history: Received 24-03-2022 Accepted 22-06-2022 Available online 31-07-2023 Keywords: Covid-19 Vaccination Treatment outcome Northeast India ABSTRACT Background: Vaccination has been recommended to curve the COVID-19 pandemic. Associations of death among COVID-19 patients with their COVID-19 vaccination status and various co-morbidities are ill understood. Objectives: To compare the proportions of death between COVID-19 vaccinated and un-vaccinated and to determine the association of vaccination status and selected co-morbidities with death among COVID-19 patients treated in the DCH of Tripura. Materials and Methods: This secondary data based cross-sectional study was conducted in the DCH of Agartala Government Medical College using medical records of 2354 COVID-19 patients treated during second and third quarters of 2021, chosen by simple random sampling. A pre-designed proforma was used to extract data regarding demographics, vaccination status, co-morbidities, vitals, treatment outcome etc. from the case-sheets. Binary regression model was utilized for predicting the probability of death due to COVID-19 using important predictor variables. Result: Majority i.e. 68% patients were aged between 18 to ≤60 yr, 56.7% were male, 38.3% had co- morbidities, 11% received single dose, 9.6% received two doses and 79.4% had no COVID-19 vaccination. Death rate was 5.8% among first dose recipients, 9.3% among second dose recipients and 11.4% among un- vaccinated. Overall death rate was 7.4%. Binary regression model has shown that older age, poor oxygen saturation during hospitalization, chronic kidney disease, hypertension and diabetes mellitus are having significant enhancing effect and vaccination having protective effect upon death. Conclusion: Old age, diabetes mellitus, hypertension and chronic kidney disease have enhancing and vaccination has got protective effect against death due to COVID-19. This is an Open Access (OA) journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. For reprints contact: reprint@ipinnovative.com 1. Introduction Corona Virus Disease 2019 (COVID-19) attracted worldwide attention by causing international public health emergency in the form of pandemic. Globally there have been 38,35,09,779 confirmed cases of COVID-19 * Corresponding author. E-mail address: hbhattacharjya@rediffmail.com (H. Bhattacharjya). including 56,93,824 deaths reported to WHO till 3 rd February 2022 and total 10,04,07,66,359 vaccine doses have been administered till 1 st February 2022. 1 In India COVID-19 vaccination was started since 16 Jan 2021 and most healthcare and frontline workers were vaccinated with COVISHIELD ˝ o (manufactured by Serum Institute of India Pvt Ltd, Pune, India). The process of vaccinating the elderly https://doi.org/10.18231/j.pjms.2023.067 2249-8176/© 2023 Innovative Publication, All rights reserved. 352