Submit Manuscript | http://medcraveonline.com Abbreviations: CPET, cardiopulmonary exercise test; FCS, faculty of health; TCLE, term of free and informed consent; IPAQ, international questionnaire of physical activity Introduction Transfemoral amputation is a withdrawal of the limb with a cut-off level between the disarticulation of the knee and the hip joint 1 and lower limb amputations cause structural, mechanical and metabolic changes, these changes being forms of adaptation to new body condition. 2 Some metabolic alterations are more scientifcally investigated due to their physiological impact, such as metabolic expenditure (use of energy to perform activities or exercise work), oxygen consumption and anaerobic and aerobic thresholds, considering that these variables undergo general and specifc modifcations, being related to the use of auxiliary mechanisms, prostheses and their compositions. It is known that transfemoral amputees present the need to adapt to their new life condition, and the auxiliary devices require physical effort and increase in ventilation to perform their daily activities, which causes an increase in consumption and oxygen uptake, anaerobic threshold, heart rate, in order to maintain the static and dynamic balance. 3,4 When performing physical exercise, the human body makes changes in different body systems, being these: cardiovascular, hormonal, sanguineous, respiratory and skeletal muscle. 5,6 The anaerobic threshold or anaerobic threshold (LA) is the determinant of the balance between lactate production and removal, i.e., the maximum intensity of exercise. Currently, this threshold has been increasingly studied to determine physical perfomance and ventilatory performance, since it presents the peak moment of the glycolytic pathway that causes alterations in the production of lactic acid, considering that studies of VO2 max are showing more and more inconsistency for the quantifcation of aerobic capacity, being gold standard only for aerobic power. 7 In view of the greater consistency of information obtained through the anaerobic threshold, this has been used not only in scientifc articles, but also for measurement Of physical performance, in order to compare according to the age group; For the creation of protocols of physical training and treatment for determination of loads that do not promote risk stress to the cardiovascular system; And to diagnose diseases, in view of the demonstration of failures or absence of oxygen supply. 8,9 The LA has a direct interaction with the cardiovascular and respiratory systems, since, when reaching the maximum level of lactate accumulation and intensity in the metabolic and In the musculature, the activity of the autonomic nervous system increases signifcantly amplifying the parasympathetic and mainly, the sympathetic discharges, in which increases the capitation of oxygen Int Phys Med Rehab J. 2017;1(3):61‒66 61 © 2017 Sousa et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and build upon your work non-commercially. Comparison of different methods to determine the anaerobic threshold of transfemoral amputees using prosthesis Volume 1 Issue 3 - 2017 Bruna da Silva Sousa, 1 Thanyze Alice Vicentini Zoccoli,¹ Gabriela Ataides de Oliveira,¹ Lourdes Mattos Brasil,² Vera Regina Fernandes da Silva Marães 3 1 Department of Biomedical Engineering, University of Brasília, Brazil 2 Department of the Clinical Engineering, University of Brasília, Brazil 3 Department of the Physiotherapy Course, University of Brasília, Brazil Correspondence: Bruna da Silva Sousa, Department of Biomedical Engineering, University of Brasília, Brazil, Email bruzinhadolly27@gmail.com Received: May 26, 2017 | Published: June 29, 2017 Abstract Introduction: Transfemoral amputation causes cardiopulmonary, muscular and biomechanical changes that affect the physiology of physical exercise. The anaerobic threshold is one of the main indicators of the cardiopulmonary test (CPET), since it is the determinant of the balance between production and lactate removal, that is, the maximum intensity of exercise, thus determining the physical performance and ventilatory performance. The present study aims to analyze the Anaerobic Threshold (LA) of transfemoral amputees under different methods of analysis. Methodology: CPET was performed in seven unilateral transfemoral amputees using prosthesis (age 30 years ±4.89). The tests were performed in a cycle ergometer, with ramp protocol with effort measurement by the Borg Subjective Perceive Perception Scale, using the Vmax ergospirometer (CareFusion). The descriptive analysis of the data was performed by SPSS software. Results: The methods of visual graphical analysis and the method of automatic linear ventilation presented similar values in relation to the ventilatory variables, and the mathematical model and the visual graph obtained similar measures in the respiratory and cardiovascular aspects, determining the LA almost at the same time, being the Transfemoral amputee threshold is lower than predicted for age group. Conclusion: Thus, it is confirmed that the methods of graphical visual analysis and the heteroscedastic mathematical model are presented as gold standard for determination of LA, due to its sensitivity and reliability. Therefore, further studies on the determination of the anaerobic threshold in transfemoral amputees are required in order to compare with the findings in this study. Keywords: amputation, anaerobic threshold, mathematical model, physiotherapy International Physical Medicine & Rehabilitation Journal Research Article Open Access