Volume 2 • Issue 1 • 1000105 J Chem Eng Process Technol ISSN: 2157-7048 JCEPT, an open access journal Research Article Open Access Nanjwade et al. J Chem Eng Process Technol 2011, 2:1 DOI: 4172/2157-7048.1000105 Research Article Open Access Development and Characterization Salbutamol Sulphate Mouth Disintegrating Tablet Basavaraj K Nanjwade*, Ritesh Udhani, Jatin Popat, Veerendra K Nanjwade and Sachin A Thakare Department of Pharmaceutics, KLE University’s College of Pharmacy, Belgaum-590010, Karnataka, INDIA Keywords: Crospovidone XL-10; Intra and extra granular addition; Asthma; Mouth feel; Wetting time; Water absorption ratio Abbreviations: L.O.D: Loss On Drying; MCC: Micro Crystalline Cellulose Introduction Convenience of administration and patient compliance are gaining signifcant importance in the design of dosage forms. Recently more stress is laid down on the development of organoleptically elegant and patient friendly drug delivery system for pediatric and geriatric patients [1,2]. One important innovation in this direction is the development of fast dissolving/disintegrating oral dosage forms that dissolve or disintegrate instantly upon contact with recipient’s tongue or buccal mucosa [3,4]. A tablet which can rapidly disintegrate in saliva is an attractive dosage form and a patient-oriented pharmaceutical preparation [5]. Superdisintegrants are added in formulation to increase the dissolution characteristics thus increasing bioavailability of drug [6]. Tere are three methods of addition of disintegrant into the formulation, intragranular (Internal addition), extragranular (External addition), partly intragranular and extragranular addition [7]. Te time for disintegration of orally disintegrating tablets is generally considered to be less than one minute [8,9,10,11] although patients can experience actual oral disintegration times that typically range from 5-30 sec. Many companies have developed various types of fast-disintegrating dosage forms. A freeze-dried porous wafer known as Zydis [12, 13], a molding tablet known as EMP [13], an efervescent tablet known as OraSolve [13], and a disintegrant addition [13] have all been developed. Asthma is a chronic infammatory disease, which afects over 5-10% of population in industrialized countries [14]. It afects approx. 53 million people across world mostly in United States, France, Germany, Italy, Spain, United Kingdom, and Japan [14,15]. Tus, an attempt was made for preparation of fast dissolving tablets of a model bronchodilator, salbutamol sulphate with an aim of reducing lag time and providing faster onset of action to relieve immediately acute asthmatic attack. *Corresponding author: Dr. Basavaraj K. Nanjwade, Department of Pharmaceutics, KLE University College of Pharmacy, Belgaum-590010, Karnataka, India, Tel: 00919742431000; Fax: 00918312472387; E-mail: bknanjwade@yahoo.co.in Received December 07, 2010; Accepted March 15, 2011; Published March 19, 2011 Citation: Nanjwade BK, Udhani R, Popat J, Nanjwade VK, Thakare SA (2011) Development and Characterization Salbutamol Sulphate Mouth Disintegrating Tablet. J Chem Eng Process Technol 2:105. doi:10.4172/2157-7048.1000105 Copyright: © 2011 Nanjwade BK, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Abstract An orodispersible dosage form has been developed as a user-friendly formulation that disintegrates in the mouth immediately. Thus an attempt was made to improve the onset of action of bronchodilator used commonly in the treatment of asthma. Formulation was optimized for type of disintegrant used and method of formulation. Disintegrants such as CCS (Croscarmellose Sodium), SSG (Sodium Starch Glycolate), L-HPC (Low-substituted Hydroxy Propyl Cellulose), and Crospovidone XL-10 were used and tablets were prepared by direct compression method and wet granulation. Wet granulation formulation were again sub-divided where disintegrant was added intragranularly in one type and was added both in intra and extra granulation in the other. Mint favor was added to give good mouth feel. Out of all formulations prepared, the one prepared with Crospovidone XL-10 added both intra and extra granulation showed least disintegrating time (9 sec) with good fow property. Direct compression blends had poor fow. Tablets were also evaluated for various physicochemical parameters. All the tablets showed burst release of drug. Hence, it was concluded that out of all formulations, the one prepared with Crospovidone XL-10 added both intra and extra granulation was the best formulation as it showed the least disintegration time. Material and Methods Salbutamol sulphate was provided as a gif sample by Lincoln pharmaceuticals, Ahmedabad, Lactose was obtained from Ranbaxy Fine-Chem. Ltd, Delhi, MCC PH 101 and Magnesium Stearate were obtained from Loba chemicals Pvt. Ltd., Mumbai, CCS, SSG, Crospovidone XL-10 and L-HPC were obtained from Microlabs, Bangalore and Aerosil was obtained from Eonik Degussa, Mumbai. All other chemicals were of analytical grade. Equipment used UV Spectrophotometer: Systronic 2201 UV/Vis double beam Spectrophotometer. Tablet Compression Machine: Rimek 10 Station Press, Cadmach Machinery Co. Pvt. Ltd., Ahmedabad, India. Dissolution test apparatus: Dissolution test apparatus-TDT-06T, Electrolab, Mumbai, India. Roche friabilator: Camp-bell Electronics, Mumbai, India Hardness tester: Validated dial type, Model: 1101, Shivani Scientifc Industries Pvt. Ltd., Mumbai. Sartorious electronic balance: Model CP- 224 S, Labtronic. Te amount of disintegrant, lactose and MCC PH 101 was previously optimized and hence kept constant in all the formulations. Journal of Chemical Engineering & Process Technology J o u r n a l o f C h e m i c a l E n g i n e e r i n g & P r o c e s s T e c h n o l o g y ISSN: 2157-7048