Epilepsy Research (2014) 108, 1591—1596 jo ur nal ho me p ag e: www.elsevier.com/locate/epilepsyres An evaluation of serum paraoxonase together with arylesterase activities and oxidative stress in children with intractable epilepsy: A cross-sectional study Mustafa Calik a,* , Elif Oguz b , Suna Sarikaya c , Ozcan Kocaturk c , Bulent Koca d , Hatice Eke Gungor a , Nurten Aksoy e , Tahır Kurtulus Yoldas c , Akin Iscan f a Department of Pediatric Neurology, Harran University School of Medicine, Sanliurfa, Turkey b Department of Pharmacology, Harran University School of Medicine, Sanliurfa, Turkey c Department of Neurology, Harran University School of Medicine, Sanliurfa, Turkey d Department of Pediatric Cardiology, Harran University School of Medicine, Sanliurfa, Turkey e Department of Biochemistry and Clinical Biochemistry, Harran University School of Medicine, Sanliurfa, Turkey f Department of Pediatric Neurology, BezmialemVakif University, Faculty of Medicine, Istanbul, Turkey Received 29 May 2014; received in revised form 24 July 2014; accepted 21 August 2014 Available online 2 September 2014 KEYWORDS Epilepsy; Atherosclerosis; Paraoxonase; Arylesterase; Oxidative stress Summary Epilepsy is the most common chronic neurological illness in childhood and ado- lescence. The aim of this study was to investigate paraoxonase and arylesterase activities along with oxidative status parameters in children with intractable epilepsy. The study com- prised 42 subjects with intractable epilepsy and a control group of 35 healthy subjects. Serum paraoxonase and arylesterase activities, and lipid hydroperoxide levels were determined. All paraoxonase and arylesterase activities were significantly lower in the intractable epilepsy subjects than in the controls (P < 0.001), whereas lipid hydroperoxide levels were significantly higher (P < 0.05). In conclusion, paraoxonase and arylesterase activities were decreased and the lipid hydroper- oxide level was increased in patients with intractable epilepsy. These results showed that intractable epilepsy subjects may be more prone to the development of atherosclerosis. © 2014 Elsevier B.V. All rights reserved. ∗ Corresponding author at: Harran University School of Medicine, Department of Pediatric Neurology, TR-63100 Sanliurfa, Turkey. Tel.: +90 414 312 84 56; fax: +90 414 314 69 89; mobile: +90 505 284 15 68. E-mail address: m.calik80@hotmail.com (M. Calik). http://dx.doi.org/10.1016/j.eplepsyres.2014.08.007 0920-1211/© 2014 Elsevier B.V. All rights reserved.