137 JOURNAL OF NATURAL REMEDIES 1. Introduction Immunomodulation is a procedure that can alter the immune system of an organism by interfering with its functions; if it results in an enhancement of immune reactions it is named as immunostimulatory drug which primarily implies stimulation of non-specific system, i.e. granulocytes, macrophages, complement, certain T-lymphocytes and different effector substances. Immunosuppression implies mainly to reduce resistance against infections, stress and may occur on account of environmental or chemotherapeutic factors. Immunostimulation and immunosuppression both need to be tackled in order to regulate the normal immunological functioning. Hence both immunostimulating agents and immunosuppressing agents have their own standing and search for better agents exerting these activities is becoming the field of major interest all over the world [1]. Natural adjuvants, synthetic agents, antibody reagents are used as immunosuppressive and immunostimulative agents. But there are major limitation to the general use of these agents such as increased risk of infection and generalized effect throughout the effect throughout the immune system [2]. Traditional Indian system of medicines like Siddha, Ayurveda and Unani have suggested means to increase the body’s natural resistance Immunomodulatory activity of Mangifera indica L. fruits (cv Neelam) Tanveer Naved, Javed Inam Siddiqui, S. H. Ansari*, Anis A. Ansari 1 , Hayat M. Mukhtar 1. Department of AYUSH, Ministry of Health & Family Welfare, Govt. of India, Red Cross Building, New Delhi-110001. Department of Pharmacognosy and Phytochemistry, Faculty of Pharmacy, Jamia Hamdard, Hamdard Nagar, New Delhi- 110 062. Abstract Objective: To evaluate the immunomodulatory activities of ethanolic extract of Mangifera indica L. cultivar Neelam fruit pulp. Materials and methods: In the present study, the alcoholic extract of fruit pulp of M. indica has been investigated for its effect on cell mediated and humoral components of the immune system in mice. Results: Administration of test extract produced increase in humoral antibody (HA) titre and delayed type hypersensitivity (DTH) in mice. Conclusion: M. indica fruit pulp showed statistically significant immunostimulant potential in mice. * Corresponding author shansari189@rediffmail.com Vol. 5/2 (2005) 137 - 140