A Multinational Clinical Approach to Assessing the Effectiveness of Catheter- Based Ultrasound Renal Denervation: The RADIANCE-HTN and REQUIRE Clinical Study Designs Laura Mauri, Kazuomi Kario, Jan Basile, Joost Daemen, Justin Davies, Ajay J. Kirtane, Felix Mahfoud, Roland E. Schemieder, Michael Weber, Shinsuke Nanto, Michel Azizi PII: S0002-8703(17)30277-6 DOI: doi: 10.1016/j.ahj.2017.09.006 Reference: YMHJ 5529 To appear in: American Heart Journal Received date: 28 April 2017 Accepted date: 6 September 2017 Please cite this article as: Mauri Laura, Kario Kazuomi, Basile Jan, Daemen Joost, Davies Justin, Kirtane Ajay J., Mahfoud Felix, Schemieder Roland E., Weber Michael, Nanto Shinsuke, Azizi Michel, A Multinational Clinical Approach to Assessing the Effectiveness of Catheter-Based Ultrasound Renal Denervation: The RADIANCE- HTN and REQUIRE Clinical Study Designs, American Heart Journal (2017), doi: 10.1016/j.ahj.2017.09.006 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.