Dahryn Trivedi 1 , Mahendra Kumar Trivedi 1 , Alice Branton 1 , Gopal Nayak 1 , Snehasis Jana 2 * 1 Trivedi Global, Inc., Henderson, USA 2 Trivedi Science Research Laboratory Pvt. Ltd., Bhopal, India *Corresponding author: Snehasis Jana, Trivedi Science Research Laboratory Pvt. Ltd., Bhopal, India Submission: December 06, 2018; Published: December 19, 2018 Physicochemical and Thermal Analysis of the Consciousness Energy Healing Treated Ofloxacin Introduction Ofloxacin is a synthetic fluoroquinolone broad-spectrum antibiotic used to treat a variety of Gram-positive and Gram- negative bacterial infections [1]. It causes the bacterial cell death by inhibiting DNA gyrase (a type II topoisomerase and topoisomerase IV) which helps in DNA replication and repair [2]. Ofloxacin mainly used for the treatment of urinary tract infections, infections of the urethra and cervix (i.e., gonorrhoea), pneumonia, infectious diarrhoea, prostatitis, cellulitis, chronic bronchitis, plague, multidrug-resistant tuberculosis, bacterial infection of the eye and ear, otitis media when there is a hole in the eardrum, etc. [1-4]. The common side effects associated with it include a headache, vomiting, diarrhoea, seizures, psychosis, tendon rupture, numbness, skin rash, etc. [1]. It may inhibit certain drug metabolizing enzymes and thereby increase blood levels of other drugs such as theophylline, warfarin, cyclosporine, etc. It may show an increase the anticoagulant, cardiotoxicity, and arrhythmias effects when co-administered with drugs such as acenocoumarol, Quinidine barbiturate, dihydroquinidine barbiturate, etc. [4,5]. It has a shorter biological half-life, and its bioavailability is mainly dependent upon the physiological condition of the gastrointestinal tract. It is highly soluble in acidic medium and precipitates in alkaline medium thereby losing its solubility [4]. Physicochemical properties of a pharmaceutical compound play a crucial role in its dissolution, absorption, and bioavailability [6]. Many research activities are carrying out throughout the world for the improvement of these properties of the pharmaceutical or nutraceutical compounds in the formulations. In this development, the Trivedi Effect ® -Biofield Energy Healing Treatment has a significant impact on the particle size, surface area, crystallite size, and thermal properties of pharmaceutical/nutraceutical compounds [7-11]. The Trivedi Effect ® is a natural and lone scientifically established phenomenon in which an individual can harness this inherently intelligent energy from the “Universe” and transfer it anywhere on the planet through the possible mediation of neutrinos [12]. Every living organism possesses a unique, infinite, para-dimensional electromagnetic field surrounding the body, originate from the continuous movements of the charged particles, ions, cells, lymph/blood flow, heart and brain functions, etc. in the 1/8 Copyright © All rights are reserved by Dahryn Trivedi. Volume -2 Issue - 3 Research article Modern Applications in Pharmacy & Pharmacology C CRIMSON PUBLISHERS Wings to the Research Abstract Ofloxacin is a synthetic fluoroquinolone broad-spectrum antibiotic used for the treatment of both Gram-positive and gram-negative bacterial infections. In this study, the impact of consciousness energy healing treatment (the Trivedi Effect ® ) on the physicochemical and thermal properties of ofloxacin powder sample was evaluated using modern analytical techniques. The ofloxacin was divided into control and the Biofield Energy Treated sample. Only the treated ofloxacin was received the Consciousness Energy Healing Treatment remotely by a well-known Biofield Energy Healer, Dahryn Trivedi. The particle size values in the treated ofloxacin powder were significantly increased by 10.96%(d 10 ), 29.09%(d 50 ), 14.03%(d 90 ), and 12.48% {D(4,3)}; thus, the surface area was significantly decreased by 8.06% compared to the control ofloxacin. The PXRD peak intensities and crystallite sizes of the treated ofloxacin were significantly altered ranging from -70.76% to 4.73% and -70.36% to 314.81%, respectively; however, the average crystallite was significantly increased by 25.22% compared with the control sample. The latent heat of fusion and decomposition was significantly altered by 13.43% and -53%, respectively in the treated ofloxacin compared with the control sample. The total weight loss was significantly decreased by 4.19%; however, the residue amount was significantly increased by 26.97% in the treated ofloxacin compared with the control sample. Thus, the Consciousness Energy Healing Treatment (the Trivedi Effect ® ) might lead to generate a new polymorphic form of ofloxacin with better shape, appearance, flowability, and thermally more stable compared to the control sample. The Consciousness Energy Healing Treated ofloxacin would be very useful to design novel pharmaceutical formulations for the better therapeutic response against urinary tract infections, infections of the urethra, and cervix, pneumonia, cellulitis, diarrhoea, bronchitis, plague, tuberculosis, prostatitis, and otitis media, etc. Keywords: Complementary and alternative medicine; Ofloxacin; The Trivedi Effect ® ; Consciousness energy healing treatment; Particle size; PXRD; DSC; TGA/DTG ISSN 2637-7756