1358 Indian Journal of Forensic Medicine & Toxicology, July-September 2020, Vol. 14, No. 3 Correlation between Hormonal and Biochemical Changes with Kidney Function in Newly and Previously Diagnosed Women Diseased with Polycystic Ovary Syndrome Zahraa Abed al-kareem 1 , Jinan Hussein Multag 2 , Ban Hoshi Khalaf 3 , Amal Umran Mosa 4 1 M.Sc., Department of Pharmacology and Toxicology, College of Pharmacy,University of Kerbala, Kerbala, Iraq), 2 Lecturer, Dr., Karbala Hospital for Gynnecology and Obstetrics), 3 Lecturer, Dr., Department of Pharmacology and Toxicology, College of Pharmacy, University of Kerbala, Kerbala, Iraq), 4 M.Sc., Department of Pharmacology and Toxicology, College of Pharmacy, University of Kerbala, Kerbala, Iraq Abstract The objectives of our work was to identify the effects of insulin resistance and other hormonal changes on kidney function in newly and previously diagnosed women diseased with PCOS. Method: This prospective study was done by collect serum samples and urine from three group (Control 60), (previously 50), (newly 50) patients. The withdrawal led samples were subsequently assay for hormonal and biochemical changes. Results: The data of tests were available for both groups. We found signifcant differences in level of insulin, Homeostatic model assessment Insulin resistance (HOMA-IR), Homeostatic model assessment Beta function (HOMA-B), Progesterone among newly and previous women, also the data indicated a signifcant correlation between urea and testosterone in newly while direct signifcant correlation between urea and progesterone. There was signifcant correlation between Thyroid stimulating hormone (TSH) and creatinine in previously diagnosed PCOS, also direct correlation between uric acid and Body mass index (BMI), Fasting blood glucose (FBS), HOMA IR and inverse correlation with Triiodothyronine (T3) in new PCOS while in previously diagnosed PCOS there is inverse correlation between uric acid and T3. Finally, signifcant correlation between FBS, insulin, HOMA B and HOMA IR in previously diagnosed patients while correlation is seen between FBS, insulin and HOMA IR in newly patients. Keywords: Biochemical changes, kidney, women, polycystic ovary syndrome. Introduction Polycystic Ovarian Syndrome: Polycystic ovarian syndrome (PCOS) is metabolic, endocrine and genetic disorders, chronic absence of ovulation of, with clinical and biochemical changes and presentation of hyperandrogenism (1) PCOS affects as many as 10% of reproductive- age women when using the National institutes of health (NIH) standards in diagnosis. It is convenient that menstrual disturbances, insulin resistance and hyperandrogenism are currently existent, that includes anovulation, hirsutism, irregular and painful menstrual cycles, amenorrhea oligomenorrhea with small cysts in the ovaries, central obesity, and one more presentations related to the insulin resistance (2,3,4) . Epidemiology: The predisposing factors for PCOS include the following: High maternal androgen: Prenatal exposure and Onset of type 1 diabetes mellitus before menarche, insulin resistance and obesity. Drugs: such as anti-epileptic drugs (e.g., Valproate) (5) .Polycystic ovaries develop when the ovaries are stimulated to produce excessive amounts of (androgens), particularly testosterone, by either the release of excessive luteinizing hormone and