_____________________________________________________________________________________________________ # Research Associate (Siddha), † Siddha Consultant, ‡ Program Assistant (Pharmacovigilance), ¥ Research Officer, *Corresponding author: E-mail: draishwaryabalan6@gmail.com; Journal of Pharmaceutical Research International 34(50A): 30-38, 2022; Article no.JPRI.90331 ISSN: 2456-9119 (Past name: British Journal of Pharmaceutical Research, Past ISSN: 2231-2919, NLM ID: 101631759) Kadukkai- Terminalia chebula Retz. (Elixir of Rejuvenation) – A Gift of Siddha Medicine A. Aishwarya a*# , B. K. Priya b# , V. Elakkiyaa c# , T. Monika a# , P. N. Sushil Kumar a# , P. Mirunaleni a† , K. P. Chaithanya a‡ , G. Kiruthiga a¥ and B. Akila a¥ a Siddha Clinical Research Unit (Under Central Council for Research in Siddha), Ministry of AYUSH, Govt. of India, Safdarjung Hospital Campus, New Delhi-110029, India. b Siddha Central Research Institute, Arumbakkam, Chennai (Under Central Council for Research in Siddha), Ministry of AYUSH, Govt. of India, India. c Siddha Clinical Research Unit, Sri Jayachamarajendra Govt. Ayurvedic Hospital Campus, Dhanvantri Road, Bengaluru – 560009 (Under Central Council for Research in Siddha), Ministry of AYUSH, Govt. of India, India. Authors’ contributions This work was carried out in collaboration among all authors. All authors read and approved the final manuscript. Article Information DOI: 10.9734/JPRI/2022/v34i50A36435 Open Peer Review History: This journal follows the Advanced Open Peer Review policy. Identity of the Reviewers, Editor(s) and additional Reviewers, peer review comments, different versions of the manuscript, comments of the editors, etc are available here: https://www.sdiarticle5.com/review-history/90331 Received 20 June 2022 Accepted 29 August 2022 Published 12 September 2022 ABSTRACT Aim: Natural products which are gradually gaining importance because of its medicinal value in clinical research due to their well-known property of fewer or no side effects as compared to synthetic drugs. World Health Organization also advised the general public to focus on enhancing their immune system to prevent from getting affected by pandemic diseases. Methodology: In the traditional Siddha system of Medicine, there is a concept known as, ‘ Yegha Mooligai Prayogam’ (Yega – single, Mooligai – herb, and Prayogam – application) which deals with single herb and their clinical application. Polyherbal formulation were consisting of herbs, metals, and minerals but, single herb therapy is safe, convenient and economical. The concept of Single Review Article