Open Journal of Anesthesiology, 2021, 11, 12-24 https://www.scirp.org/journal/ojanes ISSN Online: 2164-5558 ISSN Print: 2164-5531 DOI: 10.4236/ojanes.2021.111002 Jan. 20, 2021 12 Open Journal of Anesthesiology Effect of Intravenous Ibuprofen on Ischemia-Reperfusion Injury Following Perioperative Tourniquet in Patients Undergoing Total Knee Arthroplasty T. Dulkadiroğlu 1 , Ş. M. Aksoy 1 , G. Uğur 2 , E. Erkılıç 2 , A. D. Özcan 2 , S. Erdoğan 2 , A. But 1 , C. Nural 2 , O. Tecimel 2 , H. Kara 1 1 Department of Anesthesiology, Faculty of Medicine, University of Yıldırım Beyazıt, Ankara, Turkey 2 Department of Anesthesiology, Ankara City Hospital, Ankara, Turkey Abstract Oxidative stress occurs in the organism with ischemia due to tourniquet use and subsequent reperfusion. Oxidative stress increases postoperative morbid- ity. Some Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) perform their anti-inflammatory effects in part by binding or inhibiting their formation of active oxygen radicals at the site of inflammation. In this study, we aimed to evaluate the effect of IV ibuprofen on ischemia-reperfusion injury (IRI) in patients undergoing total knee arthroplasty over oxidative stress parameters. The patients were randomly divided into two groups. Each patient’s protocol number, age, sex, body mass index (BMI), additional disease, drug use, tour- niquet time, hemoglobin value, additional analgesic requirement and applica- tion, adverse reaction development on the first postoperative day were rec- orded in the research follow-up form. Both groups of patients; before anes- thesia, 45 minutes after tourniquet application, 5 minutes after tourniquet lowering, 20 minutes after tourniquet lowering and at 24th-hour post-op; TOS, TAS, paraoxonase, arylesterase, myeloperoxidase, catalase, ceruloplas- min, albumin, IMA, thiol-disulfide balance tests were studied. Statistical analysis of test results was performed. We observed that antioxidants de- creased and oxidants increased on the first postoperative day in both groups in patients who underwent total knee arthroplasty. The decrease in antioxi- dant parameters was higher in IV ibuprofen doses compared to the control group in the case group; these doses indicate that the drug adversely affects the organism in the fight against oxidative stress, which is an undesirable ef- fect. To evaluate this negative effect of IV ibuprofen which is increasingly How to cite this paper: Dulkadiroğlu, T., Aksoy, Ş.M., Uğur, G., Erkılıç, E., Özcan, A.D., Erdoğan, S., But, A., Nural, C., Teci- mel, O. and Kara, H. (2021) Effect of Intra- venous Ibuprofen on Ischemia-Reperfusion Injury Following Perioperative Tourniquet in Patients Undergoing Total Knee Arth- roplasty. Open Journal of Anesthesiology, 11, 12-24. https://doi.org/10.4236/ojanes.2021.111002 Received: November 11, 2020 Accepted: January 17, 2021 Published: January 20, 2021 Copyright © 2021 by author(s) and Scientific Research Publishing Inc. This work is licensed under the Creative Commons Attribution International License (CC BY 4.0). http://creativecommons.org/licenses/by/4.0/ Open Access