Elite Journal of Haematology. Volume 2 issue 3(2024), Pp. 10-24 https://epjournals.com/journals/EJH Citation: Obeagu EI, Obeagu GU. Platelet Aberrations in HIV Patients: Assessing Impacts of ART. Elite Journal of Haematology, 2024; 2(3): 10-24 1 Platelet Aberrations in HIV Patients: Assessing Impacts of ART * Emmanuel Ifeanyi Obeagu 1 and Getrude Uzoma Obeagu 2 1 Department of Medical Laboratory Science, Kampala International University, Uganda. 2 School of Nursing Science, Kampala International University, Uganda. * Corresponding authour: Emmanuel Ifeanyi Obeagu, Department of Medical Laboratory Science, Kampala International University, Uganda, emmanuelobeagu@yahoo.com, ORCID: 0000-0002- 4538-0161 Abstract Platelet abnormalities are prevalent in HIV infection and contribute significantly to the disease's pathophysiology. Antiretroviral therapy (ART) has revolutionized HIV management but its effects on platelet function remain incompletely understood. This review provides a comprehensive overview of platelet aberrations in HIV patients, emphasizing the intricate interplay between HIV infection, ART, and platelet functionality. We discuss the mechanisms underlying platelet abnormalities, their clinical implications, and the influence of ART on platelet profiles. Additionally, we explore emerging research directions and potential therapeutic avenues to address platelet-related complications in HIV management. Understanding the complex interplay between HIV, ART, and platelets is crucial for optimizing patient care and improving outcomes in HIV management. Keywords: Platelets, HIV, Antiretroviral Therapy, Platelet Dysfunction, Platelet Aberrations, Immune Activation, Thrombocytopenia, Coagulation Disorders. Introduction Platelet aberrations represent a significant aspect of HIV pathogenesis, contributing to both the hematological and vascular complications observed in infected individuals. Thrombocytopenia, characterized by low platelet counts, is a common manifestation of HIV infection and is attributed