SUPPLEMENTARY MATERIAL Bioactive compounds and antioxidant capacity of Chuquiragua jussieui J.F.Gmel from the highlands of Ecuador Daniel A. Guerrero Bonilla a , María G. Granda-Albuja b , Mabel Guevara a , Gabriel A. Iturralde a , Tatiana Jaramillo-Vivanco c , Francesca Giampieri d and José M. Alvarez-Suarez e * a Facultad de Ingeniería y Ciencias Agropecuarias (FICA), Universidad de Las Américas, Quito, Ecuador; b Laboratorios de Investigación, Universidad de Las Américas, Quito, Ecuador; c Jardín Botánico de Quito, Quito, Ecuador; d Dipartimento di Scienze Cliniche Specialistiche ed Odontostomatologiche (DISCO)-Sez. Biochimica, Facolta di Medicina, Università Politecnica delle Marche, Ancona, Italy; e Facultad de Ingeniería y Ciencias Agropecuarias (FICA). Grupo de Investigación en Biotecnología Aplicada a Biomedicina (BIOMED), Universidad de Las Américas, Quito, Ecuador Abstract: Chuquiraga jussieui J.F.Gmel is grown at altitudes of between 3000-5000 meters above sea level throughout the Andean region of Ecuador and used by the indigenous populations of the Andes for medicinal purposes. Here, we determined the total phenolic, flavonoids, vitamin C and carotenoids content of the leaves and flowers of Ch. jussieui J.F.Gmel from different highlands of Ecuador as well as the capacity of a crude methanolic extract from the both parts of the plant to scavenge free radicals and protect red blood cell membranes from lipid oxidation. The leaves showed a high bioactive compound content in comparison to the flowers. The crude extract from the leaves proved to be more effective than the flowers in reducing iron and scavenging the DPPH, O 2 ·- and H 2 O 2 radicals, as well as in protecting cellular membrane against lipid oxidation, demonstrating that Ch. jussieui J.F.Gmel represents an important source of bioactive compounds with relevant healthy properties. Keywords: Chuquiragua jussieui J.F.Gmel, highlands of Ecuador, Bioactive compounds, antioxidant capacity. *Corresponding author: E-mail: jose.alvarez@udla.edu.ec