Accepted Manuscript Chronology of emergence of the genus Leptospira and over- representation of gene families enriched by vitamin B2, B12 biosynthesis, cell adhesion and external encapsulating structure in L. interrogans isolates from asymptomatic dogs Alongkorn Kurilung, Chantisa Keeratipusana, Tokumasa Horiike, Prapat Suriyaphol, David J. Hampson, Nuvee Prapasarakul PII: S1567-1348(18)30659-2 DOI: https://doi.org/10.1016/j.meegid.2019.04.005 Reference: MEEGID 3852 To appear in: Infection, Genetics and Evolution Received date: 28 August 2018 Revised date: 4 April 2019 Accepted date: 5 April 2019 Please cite this article as: A. Kurilung, C. Keeratipusana, T. Horiike, et al., Chronology of emergence of the genus Leptospira and over-representation of gene families enriched by vitamin B2, B12 biosynthesis, cell adhesion and external encapsulating structure in L. interrogans isolates from asymptomatic dogs, Infection, Genetics and Evolution, https://doi.org/10.1016/j.meegid.2019.04.005 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.