Results: Referrals were predominantly from private psychiatrists of patients suffering from treatment-resistant depression. The standard treatment was for 4 weeks but subject to extension. As- sessments of efficacy were based on Hamilton Depression Rating Scale (HDRS-21) and Beck’s Depression Inventory-II (BDI) scores at baseline, two weeks, and final. Additional assessments included EEG monitoring and the Repeatable Battery for Neuropsychological Assessment (RBANS). From 179 referrals, 113 patients completed sufficient sessions (2 weeks ITT) for analysis. 45 gained clinical improvement and 34 reached remission. The average improvement was 35.6Æ34%. There was a significant difference in HamD (t¼8.2,p< 0.01) and BDI (t¼6.92,p<0.01) with an Effect Size (ES) of 1.09. Four patients received maintenance rTMS and 2 “bilateral” rTMS with varied outcome. The rTMS treatment was generally well tolerated with no major side effects reported. Features that likely reflect severity of the illness, a history of suicidality or previous ECT treatment and previous rTMS, all had lower ES (w0.8). Features that may be considered exclusion criteria (anxiety or bipolar features), are actually good prognostic indicators with the highest ES values (w1.25). Features of miscellaneous psychiatric disorders as a group showed an ES at the lower end of the range (w0.7). Discussion: rTMS is a safe and effective treatment for depressive disorders and an rTMS service can be effectively delivered in a research format and a public health setting. 72 An analysis of expert/novice EEG coherence from a dental haptic simulator S. Perry a , S.M. Bridges b , M.F. Burrow c a PhD Candidate, Faculty of Education, University of Hong Kong, HKSAR b Associate Professor, Centre for the Enhancement of Teaching and Learning/ Faculty of Education, University of Hong Kong, HKSAR c Professor and Chair of Biomaterials, Melbourne Dental School, The University of Melbourne, Australia Introduction: Determining skill traits of experts allows develop- ment of training pathways, potentially enhancing the effectiveness of training. It has been seen from EEG expert/novice studies in sports and surgery, experts have a lower T3-Fz coherence than novices. This suggests that the T3 region (verbal analytic), with time and automaticity, becomes less essential. The T4 region (visual spatial) though does not appear to undergo such changes, indi- cating the visual component remains important. This theory has not yet been tested in dentistry, and its implications may help to determine the most effective skill training. Methods: 7 ‘experts’ (qualified dentists) and 8 ‘novices’ (first year dental students) volunteered for the study. Each subject was given a set time to complete a clinical and a non clinical task on a dental haptic simulator (SimodontÔ). EEG was recorded in the T3, T4 and Fz regions for coherence assessment. Results: Although there was no significant difference in the per- formances of experts and novices, a trend was evident toward lower T3-Fz and possibly T4-Fz coherence in experts when compared to novices. Non-clinical task EEG readings: (T3-Fz) Mean experts e 300 Hz, mean novices e 410 Hz, P¼ 0.15 (T4-Fz) Mean experts e 208 Hz, mean novices e 292 Hz, P¼ 0.23 For the clinical task: (T3-Fz) Mean experts e 439 Hz, mean novices e 334 Hz, P¼ 0.26 (T4-Fz) Mean experts e 333 Hz, mean novices e 218 Hz, P¼ 0.20 Discussion: This study has indicated that in dentistry, the neural networks of experts and novices may differ in relation to T3-Fz and possibly T4-Fz coherence. These results may suggest the use of verbal input, or ‘rules’ when learning a basic motor skill exercise may not be so beneficial as a visual component. Additional research in this area is essential to investigate this trend further and other aspects which may lower T3-Fz coherence. 73 Neuroregeneration and functional recovery by magnetic field stimulation and iron oxide nanoparticles in rats with spinal cord transection Suman Jain , Ajay Pal , Tapas C. Nag , Rashmi Mathur All India Institute of Medical Sciences, New Delhi, India Electromagnetic field (EMF) stimulation improves the microen- vironment for the nerve regeneration by stimulating neurotrophic factor release, attenuating oxidative stress and apoptosis after injury. Iron oxide nanoparticles (IONPs) in combination with an external electromagnetic field can also facilitate axon regeneration invitro. The present study demonstrates the in vivo potential of EMF and IONPs to facilitate regeneration in rats with complete spinal cord injury. The spinal cord was completely transected at the T11 vertebra in male albino Wistar rats. The injured rats were exposed to EMF after 24h of surgery daily for five weeks (50 Hz,17.96 mT for two hours) . In a separate group of injured rats, iron oxide nanoparticle solution (25 mg/mL) embedded in 3% agarose gel was implanted at the site of transaction and the rats subsequently exposed to EMF. BBB score was done weekly to assess locomotion and for neuroregeneration, expression of growth associated protein (GAP-43) was observed. Locomotor assessment as well as histological analysis by cresyl- violet staining demonstrated significant functional recovery and a reduction in lesion volume in rats with IONP implantation and EMF exposure. Immunohistological analysis of spinal cord tissue for GAP-43 in these rats showed a significant (P<0.001) increase in the expression and it was found to be colocalized with NeuN and NF160 as compared to SCI only group of rats. Confocal images showed abundant sprouting from mature neurons and axons near the site of lesion. Area of demyelination was also significantly less and myelinated fibers were evident at the lesion site. However, no significant difference in the expression of GFAP was evident. These findings highlight the possible therapeutic potential of IONPs along with EMF exposure in promoting neuroregeneration after SCI. 74 The Effect Of rTMS On Visual Short Term And Spatial Recognition Memory Of Female Elite Volleyball Players Of Iran N. Ansari a , M. Shojaei a , R. Rostami b , A. Daneshfar a , J. Rothwell c a Al Zahra University, Iran b University of Tehran, Iran c UCL Institute of Neurology, UK The aim of the present study was to investigate the consequences of rTMS applied over visual primary (V1) cortex area before visual short-term memory and spatial recognition memory, measuring immediate these two variables. The study was performed in 10 healthy voluntary elite volleyball female players. A double-blind, within-subject repeated measures design was used. There were two rTMS conditions: a) high frequency (10Hz) rTMS over Cz and b) high frequency (10Hz) rTMS over V1. Delayed Matching to Sample (DMS) and Spatial Recognition memory (SRM) of CANTAB batteries were used to assess visual short-term memory and spatial recog- nition memory as a visual perception motor skills function. The pre- test and post-test was performed 10 minutes before and after rTMS. we performed two way repeated measures ANOVA with main Abstracts / Brain Stimulation 8 (2015) 326e342 328