Remedy Publications LLC., | http://clinicsinoncology.com/ Clinics in Oncology 2021 | Volume 6 | Article 1836 1 Overview of Obesity and Breast Cancer in Brazil: 24 Years of Follow-Up OPEN ACCESS *Correspondence: Andrea Z Pereira, Department of Oncology and Hematology, Albert Einstein Hospital, Av. Albert Einstein, 627/520, São Paulo (SP), CEP 05651- 901, Brazil, Tel: (55 11)-3773-6590, (55 11)-2151-3203; Fax: (55 11)-2151-3522; E-mail: andreap_pereira@hotmail.com Received Date: 21 Jun 2021 Accepted Date: 12 Jul 2021 Published Date: 15 Jul 2021 Citation: Pereira AZ, de Almeida-Pitito B, do Prado RR, Mattar A, Hegg R, Yoshinori Shida J, et al. Overview of Obesity and Breast Cancer in Brazil: 24 Years of Follow-Up. Clin Oncol. 2021; 6: 1836. ISSN: 2474-1663 Copyright © 2021 Andrea Z Pereira. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Research Article Published: 15 Jul, 2021 Abstract Background: Tere is a higher risk of Breast Cancer (BC) in postmenopausal obese women and with a worse outcome of all ages. Objectives: To evaluate obesity prevalence in BC patients and its association with survival, age, Surgery Complications (SC), and molecular BC subtypes. Methods: A retrospective cohort study was performed with 5925 between 1994 and 2018. Survival analysis was performed according to Body Mass Index (BMI) groups. Te database contains information about molecular BC subtypes and SC. Results: Tey had a mean (SD) age of 54 (12.0) years. Tere were 769 (13%) deaths, and the mean survival was 20 (2.0) years. 1,787 (30%) patients with obesity and 4,138 (70%) without obesity. Patients with obesity were older (56 (11.0) years) (p<0.001) and they had lower frequencies of luminal B (33 vs. 67%, p=0.02) and HER2- (31 vs. 69%, p=0.04) subtypes. Tere was a diference between obesity in BC patients and the Brazilian population (p<0.005). Patients with obesity had more infections as a SC (p=0.01). Te Kaplan-Meier curve shows the estimates of survival for patients with obesity and patients without obesity with BC. Conclusion: We found a high prevalence of obesity in BC patients, more than in the general Brazilian women population. Our patients with obesity were older and had lower frequencies of luminal B and HER2-subtypes than women without obesity. Besides that, patients with obesity had more infections afer surgery, mainly in HER2+, Negative triple, and HER2+ Hybrid. Keywords: Breast cancer; BMI; Obesity; Follow-up-infection Andrea Z Pereira 1 *, Bianca de Almeida-Pitito 2 , Rogério Ruscitto do Prado 1 , Andre Mattar 3 , Roberto Hegg 3 , Jorge Yoshinori Shida 3 and Luiz Henrique Gebrim 3 1 Department of Oncology and Hematology, Albert Einstein Hospital, Brazil 2 Department of Preventive Medicine, UNIFESP, Brazil 3 Department of Breast Cancer, São Paulo State Government Women's Health Reference Center (Pérola Byington Hospital), Brazil Introduction Obesity is one of the signifcant public health problems of this century, being a signifcant global health epidemic in developed and developing countries [1-3]. Te future of obesity prevalence in the USA in 2030 will rise to adult obesity and severe obesity, respectively, 49% and 24%, with considerable variation across states [4]. In Brazil, among women, there was an increase in obesity over the last 25 years, from 13% to 20% [5-7]. Besides the well-established efects on type 2 diabetes and cardiovascular disease, there is convincing evidence today that obesity also increases the risk of several types of cancer, including colorectal cancer, endometrial cancer, renal cell carcinoma, esophageal adenocarcinoma, pancreatic cancer, and liver cancer [8]. Existing literature suggests a relationship between increased BMI and an increased risk for developing breast cancer [9-13], especially postmenopausal breast cancer [8]. Obesity is a risk factor for several types of cancer, including breast cancer [14]. In the world and Brazil, Breast Cancer (BC) is the primary cancer and cause of cancer deaths among the female population [15,16]. Obesity is associated with an increased risk of postmenopausal breast cancer, and some reports suggest central obesity may be associated with an increased risk of premenopausal breast cancer [12,17,18]. Many mechanisms have associated BC with obesity, mainly in the postmenopausal period, such as increased levels of estrogens due to excessive aromatization by adipose tissue; central adiposity as