Title: Epigenomic profiling of primate LCLs reveals the evolutionary patterns of epigenetic 1 activities in gene regulatory architectures 2 Authors: Raquel García-Pérez 1 * # , Paula Esteller-Cucala 1# , Glòria Mas 2,3 , Irene Lobón 1 , Valerio 3 Di Carlo 2,3 , Meritxell Riera 1 , Martin Kuhlwilm 1 , Arcadi Navarro 1,4,5 , Antoine Blancher 6,7 , 4 Luciano Di Croce 2,3,5 , José Luis Gómez-Skarmeta 8 , David Juan 1 * # , Tomàs Marquès- 5 Bonet 1,4,9,10 * # 6 Affiliations: 7 1 Institute of Evolutionary Biology (UPF-CSIC), PRBB, Barcelona, Spain 8 2 Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Spain 9 3 Universitat Pompeu Fabra (UPF), Barcelona, Spain 10 4 National Institute for Bioinformatics (INB), PRBB, Barcelona, Spain 11 5 Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain 12 6 Laboratoire d’immunologie, CHU de Toulouse, Institut Fédératif de Biologie, hôpital Purpan, 13 Toulouse, France 14 7 Centre de Physiopathologie Toulouse-Purpan (CPTP), Université de Toulouse, Centre National de 15 la Recherche Scientifique (CNRS), Institut National de la Santé et de la Recherche Médicale (Inserm), 16 Université Paul Sabatier (UPS), Toulouse, France 17 8 Centro Andaluz de Biología del Desarrollo (CABD), Consejo Superior de Investigaciones 18 Científicas-Universidad Pablo de Olavide-Junta de Andalucía, Seville, Spain 19 9 CNAG-CRG, Centre for Genomic Regulation (CRG), Barcelona Institute of Science and 20 Technology (BIST), Barcelona, Spain 21 10 Institut Català de Paleontologia Miquel Crusafont, Universitat Autònoma de Barcelona, 22 Cerdanyola del Vallès, Barcelona, Spain 23 # Contributed equally to this work 24 *Corresponding author. Email: tomas.marques@upf.edu (T.M.-B); david.juan@upf.edu (D.J.); 25 raquel.garcia@bsc.es (R.G.-P.) 26 27 . CC-BY-NC 4.0 International license perpetuity. It is made available under a preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in The copyright holder for this this version posted September 29, 2020. ; https://doi.org/10.1101/2019.12.18.872531 doi: bioRxiv preprint