272 RESEARCH AND OBSERVATION ON CLINICAL AND THERAPEUTIC ASPECTS REGARDING TRANSMISSIBLE VENEREAL TUMOR IN DOGS Muste A., Beteg F., Muste M., Stroe T., Lăcătuş R., Hodiş Loredana University of Agricultural Science and Veterinary Medicine Cluj-Napoca Faculty of veterinary Medicine, 3-5 Manastur Street, 400372, Cluj-Napoca, Romania aurel_muste@yahoo.com Abstract Transmissible venereal tumor, also known as infectious sarcoma or Sticker tumor, has a different incidence from one race to another although the range is known as a cosmopolitan character disorder. In our study. In our cases the incidence was 23%. The initial lesions are superficial, small pink to red, 1 mm to 3 mm diameter nodules can be observed, then multiple nodules fuse together forming larger, red, hemorrhagic, cauliflower-like, friable masses, that draws the owners attention. Tumors bleed easily and while becoming larger, normally ulcerate and become contaminated (Hoque, 2002). For this study two groups were used, the first group included 11 dogs, the second group 12 dogs, different race and age, all males, raised in freedom, with little socialization with other dogs. For the first group the treatment was made with vincristine sulfate at a dose of 0.025 mg/kg, i.v, administered weekly, for a period of 7 weeks. The second group was treated with vinbleastina at a dose of 0,1 mg/hg i.v, administered weekly, for 6 weeks. The best results were with vincristine, 95%, while the results for the treatment with vinblastine were between 85-95%. INTRODUCTION Transmissible venereal tumor (TVT) , also known as Sticker sarcoma or infectious sarcoma, is a benign reticuloendothelial tumor of the dogs male or female (Smith, and Washbourn, 1998) but it can be observed in wild canide (Dominguez-Tejerina et al., 1996), sexually mature. Usually it is transmited during mating (Calvet, 1983), and it is more prevalent in temperate climates (Rogers, 1997). It is commonly observed in dogs that are in close contact one with another, or in stray and wild dogs that exhibit unrestrained sexual activity (Cangul, 2003 citated by Purohit G.N.,2009). This are the explanation for the high incidence (Jain, et al. 2002) of sarcoma in the dogs, or other studies performed on dogs in the same condition.