Accepted Manuscript Synthesis and biological evaluation of N-glucosyl indole derivatives as sodium- dependent glucose co-transporter 2 inhibitors Kuang-Feng Chu, Jen-Shin Song, Chiung-Tong Chen, Teng-Kuang Yeh, Tsung-Chih Hsieh, Chung-Yu Huang, Min-Hsien Wang, Szu-Huei Wu, Chun- Hsu Yao, Yu-Sheng Chao, Jinq-Chyi Lee PII: S0045-2068(18)30789-2 DOI: https://doi.org/10.1016/j.bioorg.2018.11.006 Reference: YBIOO 2614 To appear in: Bioorganic Chemistry Received Date: 30 July 2018 Revised Date: 2 November 2018 Accepted Date: 5 November 2018 Please cite this article as: K-F. Chu, J-S. Song, C-T. Chen, T-K. Yeh, T-C. Hsieh, C-Y. Huang, M-H. Wang, S-H. Wu, C-H. Yao, Y-S. Chao, J-C. Lee, Synthesis and biological evaluation of N-glucosyl indole derivatives as sodium- dependent glucose co-transporter 2 inhibitors, Bioorganic Chemistry (2018), doi: https://doi.org/10.1016/j.bioorg. 2018.11.006 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.