Al Shafei, and Elbagory et al., (2021) JHE, 2021, 31(4): pp 25-41 . Printed in Menoufia University, Egypt. Copyrights © The JHE -25- Faculty of Home Economics Journal of Home Economics Menoufia University, Shibin El Kom, Egypt https://mkas.journals.ekb.eg Nutrition and Food Sciences Effect of Adding Lipoic Acid to Ameliorate the Flaxseed Oil for the Treatment of Rats with Hyperlipidemia Sahar O. Al Shafei 1 , Wessam S. Elbagory 1 1 Departement of Nutrition and Food Sciences, Faculty of Home Economics, Menoufia University, Shibin El-Kom, Egypt. Abstract Hyperlipidemia is a major manifestation of the pathophysiology underlying cardiovascular disease. Flaxseed oil (FO) and α-lipoic acid (LA) have been reported to exert potential benefits to the cardiovascular system. This study tried to assess The effect of adding lipoic acid to ameliorate Flaxseed oil for the treatment of rats injured by hyperlipidemia on the hyperlipidemia risk factors in rats fed a high-fat diet. The effect of adding lipoic acid to a meliorate Flaxseed oil for treatment the rats injured by hyperlipidemia. LA was dissolved in flaxseed oil with different concentrate lipoic acid (6%, 9%, 12%) and flaxseed oil 25% to rats in addition to the main food for 28 days, Thirty male albino rats weighing 150-160 grams were used in this study and were divided into 6 equal groups, each group contained 5 mice, the first group was kept as a positive control and the second group was kept as a the negative control while the other groups were fed on Diet for 4 weeks flaxseed oil and (tested) lipoic acid (P≤0.05) decreased serum lipids, serum VLDL, HDL and AI. also improve liver and kidney functions. The hypothesis of the obtained results in which flaxseed oil and lipoic acid were tested contain several compounds capable of ameliorating the adverse effects and inhibition of hyperlipidemia rats. FO and LA supplementation may contribute to the reduction of hyperlipidemia by improving the plasma lipid . Key words: HDL-c, liver and kidney function, hyperlipidemic rats, LA. Introduction Hyperlipidemia is a group of metabolic disorders characterized by elevated levels of lipids that include cholesterol, cholesterol esters, phospholipids and triglycerides (Karam et al., 2018). Lipid disorders are not dependent on total serum cholesterol, but also on its distribution among different lipoproteins. The low-density lipoproteins (LDL) are the