This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-Non Commercial- ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. © 2023 Journal of Advanced Pharmacy Education & Research | Published by SPER Publication 80 Traditional medicinal herbs for healthiness and fitness during the Covid-19 pandemic in Indonesia: literature review Nutrisia Aquariushinta Sayuti 1* , Youstiana Dwi Rusita 2 1 Department of Pharmacy, Surakarta Health Polytechnic of Health Ministry, Surakarta, Indonesia. 2 Department of Pharmaceutical and Food Analysis, Surakarta Health Polytechnic of Health Ministry, Surakarta, Indonesia. Correspondence: Nutrisia Aquariushinta Sayuti, Department of Pharmacy, Surakarta Health Polytechnic of Health Ministry, Surakarta, Indonesia. nutrisayuti@gmail.com ABSTRACT The spread of Coronavirus Disease-19 (Covid-19) has made the Indonesian people optimize their efforts to maintain health and fitness. One of the efforts is traditional medicinal herbs, especially traditional Indonesian medicine or 'jamu’, used empirically to increase immunity. The literature review aimed to describe the formula of traditional medicinal herbs in Indonesia to maintain health and fitness during the Covid-19 pandemic. The literature review searched articles on Pubmed, ScienceDirect, and Google Scholar. The selected articles were the last ten years' articles. The keyword was 'Covid-19 and herbs and immunostimulant or immunomodulator and Indonesia'. The article was published the last ten (10) years, in English or Indonesian, and discusses traditional medicinal herbs for maintaining health and fitness during the Covid-19 pandemic in Indonesia. The selection was made by reading the title, abstract, and full article to analyze the quality of the research. Data extraction was carried out to describe the formula's name, simplicia of the ingredients, pharmacological activity, and secondary metabolites. The literature review found five (5) articles that met the inclusion and exclusion criteria with thirteen (13) formulas. The formula was jamu, and the formula was from traditional Chinese medicine and Ayurveda. Each formula contained simplicia that support each other's properties for health and fitness maintenance. The simplicity was used as an immunomodulator, reducing the symptoms of Covid-19 and overcoming the comorbid factors that accompany the Covid-19 disease. The government's efforts to increase the independent actions of healthy life in Indonesia can be supported by traditional herbs. Keywords: Covid-19, Ingredients, Traditional, Health, Fitness Introduction The spread of the infectious Coronavirus Disease-19 (Covid-19), which began in 2019, affected economic stability and education in Indonesia, including the economic recession, the high mortality rate of health workers, and the emergence of distance learning. The first case of Covid-19 infection in Indonesia was reported in March 2020 [1] . Covid-19 had been increasing in the past two years until the Indonesian government issued a vaccine policy to prevent Covid-19 starting in January 2021 [2]. Drug classification of Covid-19 consists of antiviral, antimalarial, antidiabetic, glucocorticoid, antibiotic, antiparasitic, anti- tuberculosis, antiasthma, antithrombotic, anticoagulant, phosphoinositide 3-kinase (PI3K) inhibitory agent, anticancer agent, human ACE2 agent, recombinant human deoxyribonuclease (rhDNase) enzyme, immunotherapy and convalescent plasma therapy (CPT). Adjuvant therapy using supplements, nutraceuticals, and herbal medicines is also needed to relieve symptoms and improve the healing process in patients with Covid-19 [3, 4]. The use of medicinal plants in traditional medicinal herbs (called "Jamu" in Indonesia) has increased during the Covid-19 pandemic in Indonesia. Some medicinal herbs or "Jamu" have been used to maintain health and fitness, especially as immunomodulators, although only limited to empirical evidence [5]. The problem of immunity is closely related to health-related quality of life (HRQoL), empowerment of patient/community, and satisfaction with health care [6]. The differences in countries and beliefs lead to the differences in HRQoL because it's related Access this article online Website: www.japer.in E-ISSN: 2249-3379 How to cite this article: Sayuti NA, Rusita YD. Traditional medicinal herbs for healthiness and fitness during the Covid-19 pandemic in Indonesia: literature review. J Adv Pharm Educ Res. 2023;13(1):80-92. https://doi.org/10.51847/aFldpZuj5h