MOL # 3889 1 Cellular Topoisomerase I Inhibition and Antiproliferative Activity by MJ-III-65 (NSC 706744), an Indenoisoquinoline Topoisomerase I Poison SMITHA ANTONY, GLENDA KOHLHAGEN, KELI AGAMA, MUTHUSAMY JAYARAMAN, SHOUSONG CAO, FARUKH DURRANI, YOUCEF M. RUSTUM, MARK CUSHMAN and YVES POMMIER Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892-4255 (S.A., G.K., K.A., Y.P.), Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, Indiana 47907-1333 (M.J., M.C.), and Grace Cancer Drug Center, Roswell Park Cancer Institute, Buffalo, N.Y. 14263 (S.C., F.D., Y.M.R.) Molecular Pharmacology Fast Forward. Published on November 5, 2004 as doi:10.1124/mol.104.003889 Copyright 2004 by the American Society for Pharmacology and Experimental Therapeutics. This article has not been copyedited and formatted. The final version may differ from this version. Molecular Pharmacology Fast Forward. Published on November 5, 2004 as DOI: 10.1124/mol.104.003889 at ASPET Journals on January 16, 2022 molpharm.aspetjournals.org Downloaded from