Contents lists available at ScienceDirect Respiratory Medicine Case Reports journal homepage: www.elsevier.com/locate/rmcr Case report Azygos lobe: A rare cause of right paratracheal opacity Jamal Akhtar a,∗ , Amos Lal a , Kevin B. Martin b , Joel Popkin a a Department of Internal Medicine, Saint Vincent Hospital, Worcester, MA, USA b Pulmonary Division, Reliant Medical Group, Worcester, MA, USA ARTICLE INFO Keywords: Azygos lobe Azygos fissure Rare variant ABSTRACT A 55 year old male presented with a complaint of dyspnea and non productive cough. He was found to have right paratracheal opacity on Chest X ray. Chest CT scan revealed right sided azygos lobe. An azygos lobe is a rare congenital variant of the right lung, usually diagnosed as an incidental finding. 1. Introduction An azygos lobe is a rare congenital variant usually of the right lung, not a true separate lobe. It is important to have a good understanding of the entity, as it can mimic certain pathological conditions like bullae, abscesses or lung masses. It is also important in preparation for surgical procedures. 2. Case report A 55 year old male presented with a complaint of dry cough and dyspnea. A chest x ray revealed right paratracheal opacity (Fig. 1). The chest CT showed minor air space disease with an air bronchogram in the left lower lobe. There was also tree in bud nodularity with scattered subcentimeter ground glass nodules involving the left lower lobe. It also incidentally revealed an azygos fissure along with an azygos lobe on the right side (Fig. 2a and 2b). He was treated for pneumonia. 3. Discussion An azygos lobe is a rare normal anatomic variant of the right upper lobe, first described by Heinrich Wrisberg in 1778 [1]. Its prevalence varies from 0.4% on chest radiograph to 1.2% on high resolution CT scans. It is usually diagnosed incidentally on imaging [2]. It is typically located in the apicomedial portion of the right lung, separated from the rest of the right upper lobe by a visible fissure, termed an azygous fissure. The fissure can be identified as a fine, convex line on a chest radiograph in the para mediastinal portion of the right lung. The upper most part of the fissure is triangular shaped and known as “triagonum parietale” containing a small amount of areolar tissue between the parietal layers of pleura. The lower most portion of the azygos fissure is tear drop shaped and contains the azygos vein [3]. The azygos vein is normally formed by the union of the right sub- costal vein and the right ascending lumbar vein at the level of the L1/L2 vertebrae. It enters through the diaphragmatic aortic hiatus into the thoracic cavity, ascends along the anterolateral surface of the thoracic vertebrae, takes a curve at T4 and then joins the superior vena cava. The azygos vein arch appears as a tear drop on x ray and is normally located at the caudal point of the right paratracheal stripe, at the right tracheobronchial angle. The azygos lobe is formed when the right posterior cardinal vein, which is one of the precursors of the azygos vein penetrates the right lung apex, rather than migrating over it. The cardinal vein carries both pleural layers with it, resulting in entrapment of a portion of the right upper lobe. The double folds of visceral and parietal pleura form a mesentery like structure, termed the mesoaygos or azygos fissure, containing the azygos vein arch in its lower most portion [4]. The azygos lobe is not truly a separate lobe, as it does not have its own bronchus and does not correspond to a specific bronchopulmonary segment. Embryologically the azygos lobe is a part of the right upper lobe and its bronchial and arterial supplies arise from the apical or posterior segments of the right upper lobe [5,6]. Left azygos lobe has been reported as well, but it is extremely rare [7,8]. Understanding the structure of the azygos lobe is important. It can mimic bullae, abscesses or a paratracheal opacity [9,10]. Sometimes the azygos vein located in the lower most part of azygous fissure can mimic a pulmonary nodule [3]. Consolidation of the azygos lobe can mimic a lung mass [3]. For thoracoscopic procedures, recognition of the azygos lobe is particularly important as partial obstruction of surgical site view during thoracoscopic sympathectomy has been reported by Smith et al. [11]. Two cases were reported by Bancroft et al. where the phrenic nerve was coursing within the azygos fissure [12]. The azygos fissure or pleural folds helps in preventing dissemination of the infection to the azygos lobe from adjacent parts of the lung. However, multiple cases of https://doi.org/10.1016/j.rmcr.2018.02.001 Received 16 December 2017; Received in revised form 1 February 2018; Accepted 1 February 2018 ∗ Corresponding author. Department of Internal Medicine, Saint Vincent Hospital, Worcester, MA, USA. E-mail address: jamal.akhtar@stvincenthospital.com (J. Akhtar). Respiratory Medicine Case Reports 23 (2018) 136–137 2213-0071/ © 2018 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/). T